A Comparative Analysis of Completed Suicide Using High Resolution Brain SPECT Imaging

Amen Clinic, Department of Research and Information Systems, 4019 Westerly Pl., Suite 110, Newport Beach, CA 92660, USA.
The Journal of Neuropsychiatry and Clinical Neurosciences (Impact Factor: 2.82). 10/2009; 21(4):430-9. DOI: 10.1176/appi.neuropsych.21.4.430
Source: PubMed


The authors compared regional cerebral blood flow in the brains of 12 psychiatric patients who completed the act of suicide with groups of healthy and nonsuicidal depressed subjects using statistical parametric mapping. Results were consistent with prior imaging studies on depression and were indicative of impaired impulse control and limbic dysregulation, including significant perfusion deficits in the medial prefrontal and subgenual areas (Brodmann's areas 11, 25) and ventral tegmentum. These results warrant further research.

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Available from: Daniel G. Amen, Jun 25, 2014
    • "In addition , decreased fractional anisotropy in the cingulum bundle is observed in suicidal traumatic brain-injured patients (Yurgelun- Todd et al., 2011). More diagnostically-heterogeneous populations with past suicide attempts show functional disturbances in medial and lateral PFC sectors during varied cognitive tasks (Audenaert et al., 2002; Amen et al., 2009; Jollant et al., 2010; Reisch et al., 2010). These studies, while preliminary, suggest that patients with suicidal behavior exhibit dysfunction of PFC-based circuits during complex cognition, and may be impaired over and above those patients who share other clinical features (e.g. "
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