Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy).
ABSTRACT Insulin resistance, obesity, hypertension, and dyslipidemia are strongly associated with metabolic syndrome (MeSy), which is considered to be a reversible clinical stage before its evolution to coronary heart disease and diabetes. Currently, the antihypertensive and hypolipidemic properties of aqueous Hibiscus sabdariffa extracts (HSE) have been demonstrated in clinical trials and in vivo experiments. The aim of the present study was to evaluate the effects of a Hibiscus sabdariffa extract powder (HSEP) and a recognized preventive treatment (diet) on the lipid profiles of individuals with and without MeSy according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. The protocol was a follow-up study carried out in a factorial, randomized design (T1=preventive treatment comprises Diet, T2=HSEP, T3=HSEP+preventive treatment (Diet) X MeSy, non-MeSy individuals). A total daily dose of 100 mg HSEP was orally administered in capsules for one month. The preventive treatment (diet) was selected according to NCEP-ATP III recommendations and adjusted individually. Total cholesterol, LDL-c, HDL-c, VLDL-c, triglycerides, glucose, urea, creatinine, AST, and ALT levels in the blood were determined in all individuals pre- and post-treatment. The MeSy patients treated with HSEP had significantly reduced glucose and total cholesterol levels, increased HDL-c levels, and an improved TAG/HDL-c ratio, a marker of insulin resistance (t-test p<0.05). Additionally, a triglyceride-lowering effect was observed in MeSy patients treated with HSEP plus diet, and in individuals without MeSy treated with HSEP. Significant differences in total cholesterol, HDL-c, and the TAG/HDL-c ratio were found when the means of absolute differences among treatments were compared (ANOVA p<0.02). Therefore, in addition to the well documented hypotensive effects of Hibiscus sabdariffa, we suggest the use of HSEP in individuals with dyslipidemia associated with MeSy.
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ABSTRACT: This study reports the phytochemical profile (phenolics, flavonoids and anthocyanins), the antioxidant capacity and the antibacterial activity of the ethanolic extracts of a collection of 25 Mexican Hibiscus sabdariffa (Hs) varieties with different calyx color intensities, from green–yellow to deep red, cultivated in the same condition. A great variety of phenolic compounds were identified in the different extracts using HPLC-DAD-ESI-TOF-MS, mainly phenolic acids, flavonoids, and anthocyanidin, some of which have been described for the first time. The total phenolic, flavonoid and anthocyanidin contents showed great variation in the different Hs extracts, ranging from 2400 ± 300 to 10,000 ± 400 mg gallic acid equivalents (GAE)/100 g dry calyx (dc), from 419 ± 2 to 2260 ± 70 mg quercetin/100 g dc, and from 0 to 4408 mg/100 g dc with different ratios of delphinidin:cyanidin, respectively. Furthermore, the antioxidant capacity determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay presented the same behavior, with values that varied from 27.4 ± 0.3 to 112 ± 8 mol equivalent trolox/g dc. In addition, the antibacterial activity of the HS extracts was assayed against Gram-negative (Escherichia coli, Salmonella enteritidis) and Gram-positive (Staphylococcus aureus, Micrococcus luteus) microorganisms, demonstrating that the ethanol extracts were effective against all the bacterial strains tested, showing a greater effect against Gram-positive bacteria. Finally, a multivariate analysis for the classification of the Hs varieties has been carried out based on the anthocyanidin content. The results reported in this paper shows for the first time antibacterial and phytochemistry diversity of the different varieties of Hs, which highlights the importance of a correct description of Hs materials used in research papers.Industrial Crops and Products 07/2015; 69. DOI:10.1016/j.indcrop.2015.02.053 · 3.21 Impact Factor
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ABSTRACT: Introduction: Several studies have demonstrated Hibiscus sabdariffa L administration effects on weight reduction in experimental models. The aim of this study was to evaluate the administration of an aqueous infusion prepared from calyxes Hibiscus sabdariffa L on body mass index, appetite and satiety in type I obese individuals. Materials and Methods: 30 adults with obesity type 1 were randomly assigned to receive an infusion of Hibiscus sabdariffa L or placebo during 3 weeks twice daily. Ponderal evaluation was performed using BMI and the effect of administration of treatment/placebo on appetite and satiety sensation was assessed by visual analog scale (VAS). Qualitative variables were expressed as absolute and relative frequencies and continuous variables as mean ± SD. Student´s t test was performed for differences between means and intragroup comparisons according time (week 1, 2 and 3) was assessed by repeated measures ANOVA´s test (GLM). Results: The individuals treated with Hibiscus sabdariffa L infusion exhibited a significant BMI reduction when compared with those receiving placebo. No significant differences were found in appetite and satiety between placebo andHibiscus-treated group in any week studied Conclusions: We demonstrated a short-term reduction in BMI by Hibiscus sabdariffa aqueous infusion administration in type I obesity individuals not related to appetite or satiety changes. A possible thermogenic effect could explain this weight reduction Keywords: Hibiscus sabdariffa, obesity, body mass index, satiety, appetite.Archivos Venezolanos de Farmacologia y Terapeutica 11/2013; 32(4):34.
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ABSTRACT: Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. A systematic review about safety and efficacy of herbal medicines in the management of obesity in human was carried out by searching bibliographic data bases such as, PubMed, Scopus, Google Scholar, Web of Science, and IranMedex, for studies reported between 30th December 2008 to 23rd April 2012 on human or animals, investigating the beneficial and harmful effects of herbal medicine to treat obesity. Actually we limited our search to such a narrow window of time in order to update our article published before December of 2008. In this update, the search terms were "obesity" and ("herbal medicine" or "plant", "plant medicinal" or "medicine traditional") without narrowing or limiting search items. Publications with available abstracts were reviewed only. Total publications found in the initial search were 651. Total number of publications for review study was 33 by excluding publications related to animals study.Studies with Nigella Sativa, Camellia Sinensis, Crocus Sativus L, Seaweed laminaria Digitata, Xantigen, virgin olive oil, Catechin enriched green tea, Monoselect Camellia, Oolong tea, Yacon syrup, Irvingia Gabonensi, Weighlevel, RCM-104 compound of Camellia Sinensis, Pistachio, Psyllium fibre, black Chinese tea, sea buckthorn and bilberries show significant decreases in body weight. Only, alginate-based brown seaweed and Laminaria Digitata caused an abdominal bloating and upper respiratory tract infection as the side effect in the trial group. No other significant adverse effects were reported in all 33 trials included in this article.In conclusion, Nigella Sativa, Camellia Synensis, Green Tea, and Black Chinese Tea seem to have satisfactory anti-obesity effects. The effect size of these medicinal plants is a critical point that should be considered for interpretation. Although there was no report for side effect in these trials, we believe that safety of these plants still remains to be elucidated by further long-term studies.06/2013; 12(1):28. DOI:10.1186/2251-6581-12-28