Denosumab, Osteoporosis, and Prevention of Fractures

New England Journal of Medicine (Impact Factor: 55.87). 11/2009; 361(22):2189; author reply 2190-1.
Source: PubMed
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    ABSTRACT: The purpose of the Materials and Methods section of a scientific manuscript is to provide information in sufficient detail, so that another scientist working in the same field of endeavor is able to repeat the experiments and reproduce the results. Authors are entitled to a justified decision on the publication or not of their work. Thus, reviewers need to assure the authors that they have studied, correctly interpreted and fairly judged their work. This can be done by writing a short introductory paragraph in their critique, mentioning the type of study, the subjects recruited, the time and places the study was conducted, the interventions, the outcome measures and the statistical tests. All these information should be found in the methods section. If the reviewer cannot find these information, he needs not to read the whole article. Reading through the abstract and the methods section, he can reject the article on good grounds. If the methods section is appropriate, then the whole article need to be further reviewed. In this manuscript we shall discuss several critical aspects of the methods and statistics from the reviewer's perspective to provide reviewers the knowledge basis to write the aforementioned introductory paragraph of their critique.
    Hippokratia 12/2010; 14(Suppl 1):13-22. · 0.37 Impact Factor
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    ABSTRACT: Osteoporosis affects all bones, including those of the facial skeleton. To date the facial bones have not drawn much attention due to the minimal probability of morbid fractures. Hearing and dentition loss due to osteoporosis has been reported. New research findings suggest that radiologic examination of the facial skeleton can be a cost-effective adjunct to complement the early diagnosis and the follow up of osteoporosis patients. Bone-mass preservation treatments have been associated with osteomyelitis of the jawbones, a condition commonly described as osteonecrosis of the jaws (ONJ). The facial skeleton, where alimentary tract mucosa attaches directly to periosteum and teeth which lie in their sockets of alveolar bone, is an area unique for the early detection of osteoporosis but also for the prevention of treatment-associated complications. We review facial bone involvement in patients with osteoporosis and we present data that make the multidisciplinary approach of these patients more appealing for both practitioners and dentists. With regard to ONJ, a tabular summary with currently available evidence is provided to facilitate multidisciplinary practice coordination for the treatment of patients receiving bisphosphonates.
    Journal of Osteoporosis 02/2011; 2011:147689. DOI:10.4061/2011/147689

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