Article

Crosstalk between the DNA damage response, histone modifications and neovascularisation.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
The international journal of biochemistry & cell biology (impact factor: 4.89). 11/2009; 42(2):193-7. DOI:10.1016/j.biocel.2009.11.020 pp.193-7
Source: PubMed

ABSTRACT Neovascularisation is critical in several malignant and inflammatory conditions, as well as in the course of eye disorders. During new vessel formation, endothelial cell functions, such as proliferation and sprouting are very important and are regulated by a variety of growth factors. The DNA damage response machinery as well as factors regulating histone modifications, such as histone deacetylases, regulate cell fate as well as gene expression. Recent evidence has pointed to potential interactions among BRCA1, H2AX and SIRT1 in these intracellular pathways and neovascularisation, which will be reviewed here.

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Keywords

DNA damage response machinery
 
eye disorders
 
factors regulating histone modifications
 
gene expression
 
growth factors
 
histone deacetylases
 
malignant
 
neovascularisation
 
potential interactions
 
Recent evidence
 

Athanassios Vassilopoulos