Glycated albumin levels are higher relative to glycated haemoglobin levels in gastrectomized subjects.
ABSTRACT In gastrectomized subjects, oral glucose tolerance test often shows marked hyperglycaemia (oxyhyperglycaemia) after glucose loading. Because serum glycated albumin (GA) has been shown to better reflect postprandial and maximum plasma glucose levels, we investigated whether or not the clinical significance of serum GA and glycated haemoglobin (HbA(1C)) in non-diabetic gastrectomized subjects differs.
During health examinations, 62 non-diabetic subjects with a history of gastrectomy and 87 non-diabetic control subjects were selected in the present study. Body mass index (BMI) in the gastrectomy group was significantly lower than in the control group.
Fasting plasma glucose levels were significantly lower in the gastrectomized subjects than in the control subjects. Although both HbA(1C) and serum GA were significantly higher in the gastrectomized subjects, there was a significant difference in GA/HbA(1C) ratio between the gastrectomized subjects and the control subjects. BMI-adjusted serum GA, based on our previous finding of inverse influence of BMI on serum GA, was also significantly higher in the gastrectomized subjects than in the controls.
Serum GA is higher relative to HbA(1C) in gastrectomized subjects. This suggests that serum GA may be a better marker than HbA(1C) for glycaemic excursion in these subjects.
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ABSTRACT: L’albumina è una proteina di notevole importanza nella fisiologia dell’organismo e alterazioni nella sua struttura e funzione possono avere rilevanti ripercussioni fisiopatologiche. è quanto accade in seguito a processi di glicossidazione che portano alla formazione dell’albumina glicata in concentrazioni elevate in caso di iperglicemia cronica o di picchi iperglicemici rilevanti. L’albumina glicata si presenta quindi non solo come un indice di controllo della malattia diabetica, ma anche come un vero e proprio fattore patogenetico. E in non poche e non poco importanti condizioni il suo utilizzo può risultare più vantaggioso della stessa emoglobina glicata. Tuttavia, a causa dei limiti iniziali di specificità delle tecniche impiegate per misurare genericamente le fruttosamine (l’insieme delle proteine glicate circolanti), e a causa del persistere di una certa confusione tra fruttosamina e albumina glicata, la determinazione di quest’ultima non ha goduto dello stesso successo dell’emoglobina glicata. In verità, con le metodiche più recenti la misurazione dell’albumina glicata nel plasma umano è divenuta sufficientemente precisa e accurata, nonchè semplice ed economica da eseguire. I risultati che stanno emergendo negli ultimi anni in merito ai progressi analitici e alle applicazioni cliniche dell’albumina glicata porteranno probabilmente nel prossimo futuro a una richiesta sempre maggiore, nell’ottica della crescente attenzione all’appropriatezza in laboratorio.Rivista Italiana della Medicina di Laboratorio 06/2012; 8(2).
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ABSTRACT: The main purpose of treating diabetes is to prevent the onset and progression of diabetic chronic complications. Since the mechanism of onset of chronic complications is still not well understood, the main strategy to achieve this purpose is to bring plasma glucose levels as close as possible to those in healthy subjects and maintain good glycemic control over the long term. Since glycation among various proteins is increased in diabetic patients compared with non-diabetic subjects, glycated protein can be used as a glycemic control indicator. Currently, among these glycated proteins, HbA1c is used as the gold standard of glycemic control indicators. However, HbA1c does not accurately reflect the actual status of glycemic control in some conditions with rapid changes in glycemic control and in patients with anemia (hemolytic anemia, iron deficiency anemia, etc.) and variant hemoglobin. In comparison, glycated albumin (GA) more accurately reflects changes in plasma glucose during the short term and postprandial plasma glucose. GA also reflects glycemic control in patients with hematologic disorders whereas GA does not reflect glycemic control in patients with disorder of albumin metabolism. GA is a glycemic control indicator which overcomes most of the disadvantages of HbA1c, and could be therefore expected to replace HbA1c as the standard glycemic control indicator in the near future. However, it is necessary to accumulate more evidences from large research studies on the effective directions for measuring GA.Clinica chimica acta; international journal of clinical chemistry 03/2014; · 2.54 Impact Factor
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ABSTRACT: Glycated albumin (GA) is known to be negatively regulated by body mass index (BMI) in non-diabetic subjects and patients with type 2 diabetes mellitus (T2DM). In non-diabetic subjects, a mechanism has been proposed in which chronic inflammation associated with obesity increases albumin metabolism and negatively regulates GA levels. However, whether this same mechanism exists in T2DM is unclear. We investigated the factor(s) which influence GA levels in T2DM patients.Clinica Chimica Acta 08/2014; 438. · 2.76 Impact Factor