Applications of Platelet-Rich Fibrin Matrix in Facial Plastic Surgery

Director of Facial Plastic Surgery, The New York Eye and Ear Infirmary, New York, New York 10003, USA.
Facial Plastic Surgery (Impact Factor: 0.64). 11/2009; 25(4):270-6. DOI: 10.1055/s-0029-1242033
Source: PubMed


Platelet concentrates enjoyed some clinical popularity in facial plastic surgery several years ago. However, interest waned due to expense, amount of blood required, equipment, space, and staff needed, and lack of clinically significant benefit. A novel, simple method of preparing an autologous platelet derivative (Selphyl; Aesthetic Factors, Princeton, NJ) allows rapid and inexpensive generation of a platelet-rich fibrin matrix (PRFM) that can be used to enhance healing after facial procedures as well as to rejuvenate the face without tissue manipulation. PRFM provides autologous, natural, but concentrated platelet growth factor release and stimulation of surrounding tissue. This article describes its use for cosmetic facial applications.

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    • "At present, however, no study has used bioluminescence imaging (BLI) to evaluate the effect of PRP on VEGFR2. PRP is a rich source of growth factors, has been found effective in accelerating significant tissue repair and regeneration, and releases massive quantities of platelet growth factors [24] [25]. It is a concentration of autologous platelets in a small volume of plasma containing several growth factors including epidermal growth factor (EGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), keratinocyte growth factor (KGF), platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-b) and vascular endothelial growth factor (VEGF) [26] [27]. "
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