Applications of Platelet-Rich Fibrin Matrix in Facial Plastic Surgery
ABSTRACT Platelet concentrates enjoyed some clinical popularity in facial plastic surgery several years ago. However, interest waned due to expense, amount of blood required, equipment, space, and staff needed, and lack of clinically significant benefit. A novel, simple method of preparing an autologous platelet derivative (Selphyl; Aesthetic Factors, Princeton, NJ) allows rapid and inexpensive generation of a platelet-rich fibrin matrix (PRFM) that can be used to enhance healing after facial procedures as well as to rejuvenate the face without tissue manipulation. PRFM provides autologous, natural, but concentrated platelet growth factor release and stimulation of surrounding tissue. This article describes its use for cosmetic facial applications.
- SourceAvailable from: Tolga Taha Sönmez
[Show abstract] [Hide abstract]
- "At present, however, no study has used bioluminescence imaging (BLI) to evaluate the effect of PRP on VEGFR2. PRP is a rich source of growth factors, has been found effective in accelerating significant tissue repair and regeneration, and releases massive quantities of platelet growth factors  . It is a concentration of autologous platelets in a small volume of plasma containing several growth factors including epidermal growth factor (EGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), keratinocyte growth factor (KGF), platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-b) and vascular endothelial growth factor (VEGF)  . "
ABSTRACT: To improve skin flap healing, one promising strategy in reconstructive surgery might be to optimize platelet rich plasma (PRP) bioactivity and the ischemia-altered expression of genes. We studied both the effect of PRP on ischemic flaps, and whether in vivo bioluminescence imaging (BLI) is a suitable method for the longitudinal monitoring of angiogenesis in surgical wounds. Axial murine skin flaps were created in four experimental groups. In vivo measurements of VEGFR2 expression levels were made every other day until the 14th day. The local VEGF level and microvessel density were quantified on the 14th day via ELISA and immunohistochemistry, and flap survival rates were measured. We demonstrated that PRP and induced ischemia have a beneficial influence on angiogenesis and flap healing. Combining the two resulted in a significantly robust increase in angiogenesis and flap survival rate that was corroborated by bioluminescence imaging of VEGFR2 activity. This study shows that angiogenic effects of PRP may be potentialized by the stimulus of induced ischemia during free flap harvesting, and thus the two procedures appear to have a synergistic effect on flap healing. This study further demonstrates that BLI of modulated genes in reconstructive surgery is a valuable model for longitudinal in vivo evaluation of angiogenesis.Biomaterials 01/2013; 34(11). DOI:10.1016/j.biomaterials.2013.01.016 · 8.31 Impact Factor
- International Journal of Trichology 01/2014; 6(1):35-36. DOI:10.4103/0974-7753.136763
- [Show abstract] [Hide abstract]
ABSTRACT: As the Internet develops, it has become an increasingly prosperous network for many types of commerce. Internet auctions have been a particularly effective form of electronic commerce and is a promising field for applying agent technologies. In many existing auction sites, some sellers deal in the same sort goods or their imitations. Buyers bid for each item on sale. Buyers cannot always purchase goods at a lower price, because buyers compete but do not cooperate with each other. Thus, buyers need to search hard to find the goods they can purchase. In this paper, we propose a bidder support system to make collusion in auctions on the Internet. In our system, buyers can purchase goods at a lower price in collusion with each other. In our system, each buyer selects a good based on his/her multi-attribute preferences. Our system supports buyer's decision making by using the analytic hierarchy process. Advantages of the bidder group support system are described as follows: each buyer can purchase a good at the lowest price, buyer's multi-attribute utilities are reflected, the mechanism is robustness for buyer's anticipation. We conducted an experiment to investigate and compare buyers' utilities between existing auctions and our system. Our experiment shows that buyers utilities in our system are sufficiently higher than these in existing auctions.