Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory inhospital pediatric cardiac arrest: a report from the National Registry of Cardiopulmonary Resuscitation.

Pediatric Critical Care Medicine (Impact Factor: 2.33). 11/2009; 11(3):362-71. DOI: 10.1097/PCC.0b013e3181c0141b
Source: PubMed

ABSTRACT Describe the use of extracorporeal cardiopulmonary resuscitation as rescue therapy in pediatric patients who experience cardiopulmonary arrest refractory to conventional resuscitation. We report on outcomes and factors associated with survival in children treated with extracorporeal cardiopulmonary resuscitation during cardiopulmonary arrest from the American Heart Association National Registry of CardioPulmonary Resuscitation.
Multicentered, national registry of in-hospital cardiopulmonary resuscitation.
Two hundred eighty-five hospitals reporting to the registry from January 2000 to December 2007.
Pediatric patients <18 yrs of age who received extracorporeal membrane oxygenation during cardiopulmonary resuscitation for in-hospital cardiopulmonary arrest.
None. MEASUREMENTS AND OUTCOMES: Prearrest and arrest variables were collected. The primary outcome variable was survival to hospital discharge. The secondary outcome was neurologic status after extracorporeal cardiopulmonary resuscitation at hospital discharge. Favorable neurologic outcome was defined as Pediatric Cerebral Performance Categories 1, 2, 3, or no change from admission Pediatric Cerebral Performance Category.
Of 6288 pediatric cardiopulmonary arrest events reported, 199 (3.2%) index extracorporeal cardiopulmonary resuscitation events were identified; 87 (43.7%) survived to hospital discharge. Fifty-nine survivors had Pediatric Cerebral Performance Category outcomes recorded, and of those, 56 (94.9%) had favorable outcomes. In a multivariable model, the prearrest factor of renal insufficiency and arrest factors of metabolic or electrolyte abnormality and the pharmacologic intervention of sodium bicarbonate/tromethamine were associated with decreased survival. After adjusting for confounding factors, cardiac illness category was associated with an increased survival to hospital discharge.
Forty-four percent of pediatric patients who failed conventional cardiopulmonary resuscitation from in-hospital cardiopulmonary arrest and who were reported to the National Registry of CardioPulmonary Resuscitation database as treated with extracorporeal cardiopulmonary resuscitation survived to hospital discharge. The majority of survivors with recorded neurologic outcomes were favorable. Patients with cardiac illness category were more likely to survive to hospital discharge after treatment with extracorporeal cardiopulmonary resuscitation. Extracorporeal cardiopulmonary resuscitation should be considered for select pediatric patients refractory to conventional in-hospital resuscitation measures.

  • Pediatric Critical Care Medicine 07/2014; 15(6):567-568. DOI:10.1097/PCC.0000000000000167 · 2.33 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To describe the risk factors for acquiring functional or cognitive disabilities during admission to a PICU.
    Pediatric Critical Care Medicine 07/2014; 15(7). DOI:10.1097/PCC.0000000000000199 · 2.33 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective to analyze the mortality and neurological outcome factors of in-pediatric intensive care unit (PICU) cardiac arrest (CA) in a multicenter international study. Patients and methods prospective observational multicenter study in Latin-American countries, Spain, Portugal, and Italy. 250 children aged from 1 month to 18 years who suffered in-PICU CA were studied. Countries and patient-related variables, arrest life, support-related variables, procedures and clinical and neurological status at hospital discharge according to the Pediatric Cerebral Performance Category (PCPC) scale were registered. The primary endpoint was survival at hospital discharge and neurological outcome at the same time was the secondary endpoint. Univariate and multivariate logistic regression analyses were performed. Results Return of spontaneous circulation maintained longer than 20 minutes was achieved in 172 patients (69.1%) and 101 (40.4%) survived to hospital discharge. In the univariate analysis oncohematologic diseases, inotropic infusion at the time of CA, sepsis and neurologic causes of CA, primary cardiac arrest, need of adrenaline, bicarbonate or volume expansion during resuscitation, and long duration of resuscitation were related with mortality. In the multivariate logistic regression analysis factors related with mortality were hemato-oncologic illness and previous treatment with vasoactive drugs at the time of CA event, neurological etiology of CA, and CPR duration for more than 10 minutes. One year after CA, neurological status assessed in 65 patients; among them 81.5% had mild disabilities or none. Conclusions Survival with good neurological outcome of CA in the PICU is improving. The most important prognostic indicator is the duration of resuscitation.
    Resuscitation 10/2014; 85(10). DOI:10.1016/j.resuscitation.2014.06.024 · 3.96 Impact Factor

Full-text (2 Sources)

Available from
Jun 1, 2014