Lipoproteins, sex hormones and inflammatory markers in association with prostate cancer
ABSTRACT To evaluate lipoprotein profile and sex hormones in patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and their possible associations with some inflammatory markers linked to PCa.
A total of 150 men (50-65 years), matched by age and body mass index (BMI), included in this study and divided into three groups according to total prostate specific antigen (PSA), digital rectal examination and prostate biopsy: 50 PCa, 50 BPH and 50 controls. Total cholesterol (Chol), HDL-chol, LDL-chol, triglycerides (TG), total testosterone (T), free T (FT), bioavailable T (BioT), estradiol and SHBG were measured. The free androgen index (FAI) and TG/HDL-chol were calculated. In 25 PCa and 25 controls, C-reactive protein (hs-CRP), adiponectin and insulin were determined.
Patients with PCa showed higher TG/HDL-chol and diminished HDL-chol than Controls and BPH. PSA correlated inversely with HDL-chol and directly with TG/HDL-chol. FAI, FT, BioT and estradiol levels were higher, and SHBG and adiponectin were lower in PCa than in Controls. No differences were found in androgens between BPH and PCa.
Our most novel findings are that the patients with PCa presented lower total Chol and HDL-chol and higher TG/HDL-chol than BPH and Controls. Patients with PCa showed higher androgens and lower adiponectin than Controls.
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ABSTRACT: The effect of water on the adsorption and photocatalytic decomposition (PCD) of formic acid on TiO2 and Pt/TiO2 was investigated using transient reaction studies, temperature-programmed desorption (TPD), and Fourier transform infrared (FTIR) spectroscopy. Reaction studies indicated that physisorbed water increased the PCD rate of formic acid to a small extent on TiO2 and to a major extent on Pt/TiO2, but the presence of only chemisorbed water did not. FTIR spectroscopy and TPD studies indicate that the main effect of the addition of water to TiO2 that had adsorbed formic acid was the displacement of formic acid. However, FTIR spectroscopy indicated that the addition of water caused a change in the adsorbed structure of formate that may be associated with the higher reactivity. These transformations can have an important influence on elementary steps in the photocatalytic decomposition of formic acid on TiO2 and Pt/TiO2.Journal of Catalysis 10/2010; 275(2):294-299. DOI:10.1016/j.jcat.2010.08.011 · 6.07 Impact Factor
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ABSTRACT: Previous studies have tested the relationship between stressful life events (LE) and cancer onset, but inconsistent results have been found. One possibility is that the LE-cancer relation may depend on other biological factors pertinent to stress and cancer. This study examined the relationship between LE and prostate specific antigen (PSA) levels, a tumor marker, and whether cortisol mediates or moderates a LE-PSA relationship. During a voluntary screening for prostate cancer risk, 139 men (mean age=57.3 years) were assessed with the Holmes and Rahe questionnaire about their LE during the past 1-5 years, and their PSA and serum cortisol levels were measured. LE and cortisol alone were unrelated to PSA. However, statistically controlling for age, body mass index and the ratio of triglycerides to HDL cholesterol, we found evidence for a synergistic interaction between LE and cortisol. Among men with low cortisol, number of LE were inversely and significantly correlated with PSA (r=-0.265, p<0.05), while in men with high cortisol, number of LE were positively and significantly correlated with PSA (r=0.344, p<0.01). These results more consistently stemmed from the effects of uncontrollable LE. Similar results were found, using a clinically significant PSA cut-off. These results suggest considering the joint effects of psychosocial and biological factors in relation to possible cancer risk, where the hypothalamic pituitary adrenal axis may moderate stress-cancer risk associations.Psychoneuroendocrinology 12/2010; 36(6):874-80. DOI:10.1016/j.psyneuen.2010.11.011 · 5.59 Impact Factor