The role of glucagon-like peptide 1 in glucose homeostasis and in other aspects of human physiology.

Edward Franek, Grzegorz Gajos, Janusz Gumprecht, Adam Krętowski, Barbara Zahorska-Markiewicz, Maciej Małecki

Journal Article: Polskie archiwum medycyny wewnȩtrznej 11/2009; 119(11):743-751.

Abstract

This paper reviews the structure, function, and pathophysiology of glucagon-like peptide 1 (GLP-1). It describes the physiology and pathophysiology of the incretin axis, of which GLP-1 is a component, as well as the biosynthesis, secretion, activity, and degradation of this intestinal hormone. Effects of GLP-1 on the endocrine function of the pancreas, cardiovascular system, central nervous system, and on water-electrolyte balance have been also presented.

Source: PubMed

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Keywords

cardiovascular system
 
endocrine function
 
GLP-1
 
glucagon-like peptide 1
 
incretin axis
 
intestinal hormone
 
paper reviews
 
pathophysiology
 
secretion
 
water-electrolyte balance