Granular cell tumor of the breast: A case report and review of literature

Institute of Pathology, Medical Faculty, University of "St Cyrill and Methodius" Street Vodnjanska bb, Skopje, 1000 Republic of Macedonia.
Cases Journal 08/2009; 2(1):8551. DOI: 10.4076/1757-1626-2-8551
Source: PubMed


A 22-year-old female patient presented with a breast mass lesion with a clinical suspicion of a fibroadenoma. Histological evaluation revealed a rare benign neoplasm - granular cell tumor.
Granular cell tumor is rare neoplasm that may arise in virtually any body site, and in 5% it occurs in the breast. The histogenesis of this tumor is still rather controversial and currently the most acceptable theory is a Schwann cell origin. The main histological feature is granular cytoplasm of the tumor cells.
From a clinical point of view there is a similarity between granular cell tumor and mammary carcinoma on mammography and ultrasound. Pathohistologically, sometimes, differential diagnostic difficulties exist concerning apocrine carcinoma, histiocytic lesions and metastatic neoplasms.

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Available from: Blagica Dukova, May 12, 2014
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