A mild favorable effect of soy protein with isoflavones on body compositiona 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women

School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR.
International journal of obesity (2005) (Impact Factor: 5). 11/2009; 34(2):309-18. DOI: 10.1038/ijo.2009.236
Source: PubMed


In vitro and animal studies suggested that soy protein and isoflavones promote weight and body fat loss. However, clinical trials in humans were few and the effects remained uncertain.
To examine whether soy protein with isoflavones and isoflavone extracts exert beneficial effects on body composition among postmenopausal women.
A double-blind randomized placebo-controlled trial was conducted among 180 postmenopausal Chinese women with mild hyperglycemia. After a 2-week adaptation, participants were randomly assigned to one of the three arms to receive 15 g soy protein and 100 mg isoflavones (Soy group), or 15 g milk protein and 100 mg isoflavones (Iso group), or 15 g milk protein (placebo group) on a daily basis for 6 months.Results:We observed a mild but significant favorable effect of soy protein with isoflavones on the changes of body weight (BW), body mass index, and body fat percentage relative to isoflavone extracts and milk protein after 6-month supplementation. The mean differences of BW between the Soy and the Iso groups were -0.75 kg (95% CI: -1.363 to -0.136, P=0.017), and between the Soy and the placebo groups were -0.60 kg (95% CI: -1.209 to -0.019, P=0.047). The mean difference of change percentage in body fat percentage between the Soy and the Iso groups was -3.74% (95% CI: -6.88 to -0.60%, P=0.02), and between the Soy and the placebo groups was -2.54% (95% CI: -5.69 to 0.12%. P=0.08).
Six-month supplementation of soy protein with isoflavones had a mild favorable effect on body composition in postmenopausal women.

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Available from: Suzanne C Ho, Apr 24, 2015
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    • "Isoflavones have healthful benefits in human obesity and a positive influence on plasma cholesterol. Izn post-menopausal women the consumption of soy protein and isoflavones or isoflavone extracts caused a reduction in body weight and fat mass (Allison et al., 2003; Liu et al., 2010) and it seems that the major fat losses were concentrated on legs (Choquette et al., 2011). Isoflavone consumption is associated with lower body mass index and lower insulin levels (Goodman-Gruen et al., 2001). "
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