Article

Randomized clinical trials in rectal and anal cancers.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Surgical Oncology Clinics of North America (Impact Factor: 1.67). 01/2010; 19(1):205-23. DOI: 10.1016/j.soc.2009.09.005
Source: PubMed

ABSTRACT This article reviews randomized clinical trials (RCTs) published between April 2001 and November 2008 on the management of patients with rectal cancer. In total, the authors reviewed 78 RCTs on therapy for rectal cancer. Of these, five met the authors' criteria for level 1a evidence. The article discusses the major RCTs and relevant findings that have impacted clinical management most and includes most but not all RCTs on therapy for rectal cancer published during this period.

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