Ureaplasma: pathogen or passenger in neonatal meningitis?

Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
The Pediatric Infectious Disease Journal (Impact Factor: 3.14). 11/2009; 29(1):60-4. DOI: 10.1097/INF.0b013e3181b21016
Source: PubMed

ABSTRACT The significance of Ureaplasma species as pathogens in neonatal meningitis remains contentious. Using an illustrative case of a premature infant with Ureaplasma parvum meningitis, confirmed by cerebrospinal fluid cultures and both specific and 16s rDNA polymerase chain reaction, we discuss the epidemiology of Ureaplasma species, the difficulties involved in diagnosis and establishing pathogenicity, and the challenges in defining appropriate treatment.

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