Article

The role of red blood cells in the progression and instability of atherosclerotic plaque.

University Cardiology Department, Medical School, Democritus University of Thrace, Voulgaroktonou 23, 68100 Alexandroupolis, Greece.
International journal of cardiology (impact factor: 7.08). 11/2009; 142(1):2-7. DOI:10.1016/j.ijcard.2009.10.031 pp.2-7
Source: PubMed

ABSTRACT This review attempts to present a focused summary of selected areas of the rapidly growing knowledge regarding the red blood cells role in atherosclerotic plaque progression and instability. A summary of the characteristics of the erythrocyte membranes is provided, followed by a brief review of the in vitro and in vivo work that has helped clarify their role in atherosclerosis. Mechanisms by which erythrocytes enter the atherosclerotic plaque and contribute to its progression and instability are presented. Finally, some elements that may be clinically important regarding erythrocytes in coronary artery disease are discussed.

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Keywords

atherosclerosis
 
atherosclerotic plaque progression
 
brief review
 
coronary artery disease
 
elements
 
erythrocyte membranes
 
erythrocytes
 
focused summary
 
growing knowledge
 
progression
 
red blood cells role
 
regarding erythrocytes
 
review attempts
 
vivo work