Celiac disease.

Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, USA.
Missouri medicine 106(5):346-50.
Source: PubMed

ABSTRACT Celiac disease is a malabsorptive disorder resulting from intolerance to gluten and leads to systemic problems due to nutritional deficiencies. Enhanced diagnostic ability through serology has led to the understanding that it is more common than previously thought and often presents in atypical and subclinical forms. Clinicians must recognize the subtle presentations that may represent celiac disease, as well as at-risk populations, so that appropriate measures can be taken to diagnose and treat the disorder.

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    ABSTRACT: The aim of this study is to explore the association between celiac disease and menstrual cycle, gestation and puerperal disorders. The association between celiac disease and menstrual cycle, gestation and puerperal disorders in a sample of 62 childbearing age women (15-49 age) was assessed within an age and town of residence matched case-control study conducted in 2008. Main outcome measures were the presence of one or more disorders in menstrual cycle and the presence of one or more complication during pregnancy. 62 celiac women (median age: 31.5, range: 17-49) and 186 healthy control (median age: 32.5, range: 15-49) were interviewed. A higher percentage of menstrual cycle disorders has been observed in celiac women. 19.4% frequency of amenorrhea was reported among celiac women versus 2.2% among healthy controls (OR = 33, 95% CI = 7.17-151.8;, p = 0.000). An association has been observed between celiac disease and oligomenorrhea, hypomenorrhea, dysmenorrhea and metrorrhagia (p < 0.05). The likelihood of having at least one complication during pregnancy has been estimated to be at least four times higher in celiac women than in healthy women (OR = 4.1, 95% CI = 2-8.6, p = 0.000). A significant correlation has emerged for celiac disease and threatened abortion, gestational hypertension, placenta abruption, severe anaemia, uterine hyperkinesia, intrauterine growth restriction (p < 0.001). A shorter gestation has on average been observed in celiac women together with a lower birth weight of celiac women babies (p < 0.001). The occurrence of a significant correlation between celiac disease and reproductive disorders could suggest to consider celiac disease diagnostic procedures (serological screening) in women affected by these disorders.
    BMC Gastroenterology 08/2010; 10:89. DOI:10.1186/1471-230X-10-89 · 2.11 Impact Factor
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    Radiology 09/2010; 256(3):783-90. DOI:10.1148/radiol.10092160 · 6.21 Impact Factor
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    BMC Gastroenterology 02/2014; 14(1):38. DOI:10.1186/1471-230X-14-38 · 2.11 Impact Factor
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