Article

Worldwide variations in colorectal cancer. CA Cancer J Clin

Department of Surveillance and Health Policy Research, American Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, USA.
CA A Cancer Journal for Clinicians (Impact Factor: 162.5). 11/2009; 59(6):366-78. DOI: 10.3322/caac.20038
Source: PubMed

ABSTRACT Previous studies have documented significant international variations in colorectal cancer rates. However, these studies were limited because they were based on old data or examined only incidence or mortality data. In this article, the colorectal cancer burden and patterns worldwide are described using the most recently updated cancer incidence and mortality data available from the International Agency for Research on Cancer (IARC). The authors provide 5-year (1998-2002), age-standardized colorectal cancer incidence rates for select cancer registries in IARC's Cancer Incidence in Five Continents, and trends in age-standardized death rates by single calendar year for select countries in the World Health Organization mortality database. In addition, available information regarding worldwide colorectal cancer screening initiatives are presented. The highest colorectal cancer incidence rates in 1998-2002 were observed in registries from North America, Oceania, and Europe, including Eastern European countries. These high rates are most likely the result of increases in risk factors associated with "Westernization," such as obesity and physical inactivity. In contrast, the lowest colorectal cancer incidence rates were observed from registries in Asia, Africa, and South America. Colorectal cancer mortality rates have declined in many longstanding as well as newly economically developed countries; however, they continue to increase in some low-resource countries of South America and Eastern Europe. Various screening options for colorectal cancer are available and further international consideration of targeted screening programs and/or recommendations could help alleviate the burden of colorectal cancer worldwide.

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    • "Garland et al. demonstrated an inverse correlation between dietary calcium (Ca 2+ ) intake and the risk of colorectal cancer (CRC), identifying nutritional Ca 2+ as a promising chemopreventive agent [1]. Since then several advances have been made with focus on studies trying to establish risk factors to facilitate suitable intervention in CRC [1] [2] [3]. "
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    ABSTRACT: An inverse correlation between dietary calcium intake and the risk of colorectal cancer (CRC) is well known, but poorly understood. Expression of the calcium-sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is downregulated in CRC leading us to hypothesize that the CaSR has tumor suppressive roles in the colon. The aim of this study was to understand whether restoration of CaSR expression could reduce the malignant phenotype in CRC. In human colorectal tumors, expression of the CaSR negatively correlated with proliferation markers whereas loss of CaSR correlated with poor tumor differentiation and reduced apoptotic potential. In vivo, dearth of CaSR significantly increased expression of proliferation markers and decreased levels of differentiation and apoptotic markers in the colons of CaSR/PTH double knock-out mice confirming the tumor suppressive functions of CaSR. To prove that normally functioning CaSR is indeed important to maintain the balance between proliferation-differentiation-apoptosis, we extended the study in vitro. CRC cells stably overexpressing wild-type CaSR showed significant reduction in proliferation, as well as increased differentiation and apoptotic potential. The positive allosteric modulator of CaSR, NPS R-568 further enhanced these effects, whereas treatment with the negative allosteric modulator, NPS 2143 inhibited these functions. Interestingly, the dominant-negative mutant (R185Q) was able to abrogate the effects of calcium. Our results demonstrate a critical tumor suppressive role of CaSR in the colon. Restoration of CaSR expression and function is linked to regulation of the balance between proliferation, differentiation, and apoptosis and provides a rationale for novel strategies in CRC therapy. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 02/2015; 1. DOI:10.1016/j.bbamcr.2015.02.011 · 5.30 Impact Factor
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    • "CRC is the third most common cancer and the number one cause of nonsmoking cancer-related deaths in the world (Ferlay et al., 2010). Globally, there is a wide variability in the incidence of CRC, with the highest incidence in Australia, New Zealand, Europe and North America, and the lowest in Africa and Asia (Center et al., 2009; Jemal et al., 2011). Although developing countries historically have a low rate of CRC, a recent study by Chalya et al. (2013) revealed that CRC is reported to be increasing in resource-limited countries, probably due to the acquisition of a western lifestyle. "
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    Phytotherapy Research 02/2015; DOI:10.1002/ptr.5310 · 2.40 Impact Factor
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    • "In fact, the most common cancer among Malaysian men during the period of 2007 until 2011 was colorectal, followed by lung cancer whereas colorectal cancer came in second after breast cancer in women [3]. Colorectal cancer is the second most common cause of death with 3500 cases per year and has become a major public problem [4]. "
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    ABSTRACT: The preliminary study is aimed at evaluating the cytotoxic activity of crude extracts from the stem bark of Canarium odontophyllum against colorectal carcinoma cell HCT 116. Result of the extraction yield showed that distilled water produced the highest yield (10.58%) followed by methanol (6.55%) whereas acetone extracted the lowest yield (4.58%) from C. odontophyllum stem bark. Phytochemical screening test revealed the presence of terpenoid, flavonoid, tannin, saponin and phenolic compound in all the stem bark extracts of C. odontophyllum. Acetone extract of C. odontophyllum stem bark showed significantly higher (p < 0.05) cytotoxic effect with IC50 of 0.062 ± 1.04 mg/ml compared to methanol extract with IC50 0.122 ± 4.92 mg/ml. No cytotoxic effect was observed by the aqueous extract despite its high extraction yield. In conclusion, acetone and methanol extracts from C. odontophyllum stem bark exhibited promising cytotoxic activity against human colorectal cancer cell line HCT 116 and paves way for further investigation in view of its mode of cancer cell death.
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