Steroids from Monascus purpureus metabolite

Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100083, China.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 07/2009; 34(14):1809-11.
Source: PubMed


To study the chemical constituents of Monascus purpureus metabolite.
The compounds were isolated by column chromatography methods, and their structures were determined by spectroscopic methods.
Eight compounds were isolated from the petroleum ether fraction of ethanolic extract and elucidated as stigmast-4-en-3-one (1), 3-oxo-24-methylenecycloarane (2), stigmasterol (3), 7beta-hydroxystigmasterol (4), 3beta-hydroxystigmast-5-en-7-one (5), 3beta-hydroxystigmast-5,22-dien-7-one (6), 5alpha, 8alpha-epidioxyergosta-6,22-dien-3beta-ol (7), sitosterol (8).
All of the compounds were isolated from this genu for the first time except compound 3 and 7.

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