Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy.
ABSTRACT Se-ing is believing: Many proteins are cross-braced by disulfide bonds that frequently play key roles in protein structure, folding, and function. Unfortunately, the methods available for assignment of disulfide-bond connectivities in proteins are technically difficult and prone to misinterpretation. Now disulfide bond connectivities in native proteins can be visualized directly using 77Se NMR spectroscopy.
- SourceAvailable from: venomics.euExpert Review of Proteomics 07/2009; 6(3):221-4. · 3.90 Impact Factor
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