Article

3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease.

IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
Free radical research (impact factor: 2.22). 11/2009; 44(1):74-89. DOI:10.3109/10715760903300709 pp.74-89
Source: PubMed

ABSTRACT The aim of the present study was to examine the effects of 3,5-dicaffeoyl-4-malonylquinic acid (CA1), extract from Centella Asiatica, in rats subjected to experimental colitis.
Colitis was induced in rats by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). CA1 was administered daily orally (0.2 or 2 mg/kg). Four days after DNBS administration, treatment with CA1 significantly reduced the appearance of diarrhoea and the loss of body weight. This was associated with a significant reduction in colonic MPO activity. CA1 also reduced NF-kappaB activation, the pro-inflammatory cytokines release, the appearance of I-NOS, nitrotyrosine, PARP and proMMP-9 and -2 activity in the colon and reduced the up-regulation of ICAM-1 and the expression of P-Selectin.
The results of this study suggested that administration of CA1 may be beneficial for treatment of inflammatory bowel disease.

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Keywords

-2 activity
 
3,5-dicaffeoyl-4-malonylquinic acid
 
Centella Asiatica
 
colonic MPO activity
 
dinitrobenzene sulphonic acid
 
experimental colitis
 
inflammatory bowel disease
 
intracolonic instillation
 
NF-kappaB activation
 
nitrotyrosine
 
P-Selectin
 
proMMP-9
 
rats
 
up-regulation