Article

Horizontal Guided Bone Regeneration in the Posterior Maxilla Using Recombinant Human Platelet-Derived Growth Factor: A Case Report

Loma Linda University, Loma Linda, Calif, USA.
Journal of Oral Implantology (Impact Factor: 0.98). 10/2009; 35(5):251-6. DOI: 10.1563/AAID-JOI-D-09-00004.1
Source: PubMed

ABSTRACT This clinical case report describes and demonstrates successful use of recombinant human platelet-derived growth factor (rhPDGF-BB) in conjunction with autogenous bone, anorganic bone mineral, and barrier membranes to reconstruct severe alveolar bone defects. A combined sinus augmentation and vertical alveolar ridge augmentation was successfully performed. In addition, a significant amount of periodontal bone gain was achieved in close apposition to a previously denuded root surface, which is significant from a periodontal standpoint, given the possibility of vertical periodontal regeneration.

Download full-text

Full-text

Available from: Istvan Urban, Aug 15, 2014
1 Follower
 · 
99 Views
  • Source
    • "The results demonstrated successful use of recombinant human platelet-derived growth factor-BB in conjunction with autogenous bone, anorganic bone mineral, and barrier membranes to reconstruct severe alveolar bone defects (Urban et al., 2009). A significant amount of periodontal bone gain was achieved in close apposition to a previously denuded root surface, giving the possibility of vertical periodontal regeneration (Urban et al., 2009). "
    Implant Dentistry - The Most Promising Discipline of Dentistry, 09/2011; , ISBN: 978-953-307-481-8
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Saccadic oscillations are unwanted back-to-back saccades occurring one upon the other that produce a high-frequency oscillation of the eyes (usually 15-30 Hz). These may occur transiently in normal subjects, for example, around the orthogonal axis of a purely horizontal or vertical saccade, during combined saccade-vergence gaze shifts or during blinks. Some subjects may produce saccadic oscillations at will, usually with convergence. Pathological, involuntary saccadic oscillations such as flutter and opsoclonus are prominent in certain diseases. Our recent mathematical model of the premotor circuit for generating saccades includes brainstem burst neurons in the paramedian pontine reticular formation (PPRF), which show the physiological phenomenon of post-inhibitory rebound (PIR). This model makes saccadic oscillations because of the positive feedback among excitatory and inhibitory burst neurons. Here we review our recent findings and hypotheses and show how they may be reproduced using our lumped model of the saccadic premotor circuitry by reducing the inhibitory efficacy of omnipause neurons.
    Progress in brain research 02/2008; 171:123-30. DOI:10.1016/S0079-6123(08)00616-X · 5.10 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Leukocyte- and platelet-rich fibrin (L-PRF) is a biomaterial commonly used in periodontology and implant dentistry to improve healing and tissue regeneration, particularly as filling material in alveolar sockets to regenerate bone for optimal dental implant placement. The objective of this work was to evaluate the use of L-PRF as a safe filling and hemostatic material after dental extractions (or avulsions) for the prevention of hemorrhagic complications in heart surgery patients without modification of the anticoagulant oral therapy. Fifty heart surgery patients under oral anticoagulant therapy who needed dental extractions were selected for the study. Patients were treated with L-PRF clots placed into 168 postextraction sockets without modification of anticoagulant therapy (mean international normalized ratio  =  3.16 ± 0.39). Only 2 patients reported hemorrhagic complications (4%), all of which resolved a few hours after the surgery by compression and hemostatic topical agents. Ten patients (20%) showed mild bleeding, which spontaneously resolved or was resolved by minimal compression less than 2 hours after surgery. No case of delayed bleeding was reported. The remaining 38 patients (76%) showed an adequate hemostasis after the dental extractions. In all cases, no alveolitis or painful events were reported, soft tissue healing was quick, and wound closure was always complete at the time of suture removal one week after surgery. The proposed protocol is a reliable therapeutic option to avoid significant bleeding after dental extractions without the suspension of the continuous oral anticoagulant therapy in heart surgery patients. Other applications of the hemostatic and healing properties of L-PRF should be investigated in oral implantology.
    Journal of Oral Implantology 06/2011; 37(6):681-90. DOI:10.1563/AAID-JOI-D-11-00001 · 0.98 Impact Factor
Show more