Article

KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucl Acids Res 38:D355-D360

Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Nucleic Acids Research (Impact Factor: 9.11). 10/2009; 38(Database issue):D355-60. DOI: 10.1093/nar/gkp896
Source: PubMed

ABSTRACT Most human diseases are complex multi-factorial diseases resulting from the combination of various genetic and environmental
factors. In the KEGG database resource (http://www.genome.jp/kegg/), diseases are viewed as perturbed states of the molecular system, and drugs as perturbants to the molecular system. Disease
information is computerized in two forms: pathway maps and gene/molecule lists. The KEGG PATHWAY database contains pathway
maps for the molecular systems in both normal and perturbed states. In the KEGG DISEASE database, each disease is represented
by a list of known disease genes, any known environmental factors at the molecular level, diagnostic markers and therapeutic
drugs, which may reflect the underlying molecular system. The KEGG DRUG database contains chemical structures and/or chemical
components of all drugs in Japan, including crude drugs and TCM (Traditional Chinese Medicine) formulas, and drugs in the
USA and Europe. This database also captures knowledge about two types of molecular networks: the interaction network with
target molecules, metabolizing enzymes, other drugs, etc. and the chemical structure transformation network in the history
of drug development. The new disease/drug information resource named KEGG MEDICUS can be used as a reference knowledge base
for computational analysis of molecular networks, especially, by integrating large-scale experimental datasets.

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