Article

Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazides.

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
Organic & Biomolecular Chemistry (Impact Factor: 3.57). 11/2009; 7(22):4641-6. DOI:10.1039/b914265g
Source: PubMed

ABSTRACT Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.

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Jun 11, 2012