Article

The effects of hyperbaric oxygen on tooth movement into the regenerated area after distraction osteogenesis.

The Cleft Palate-Craniofacial Journal (impact factor: 0.82). 10/2009; 47(4):382-92. DOI:10.1597/09-016.1 pp.382-92
Source: PubMed

ABSTRACT Abstract Objective: To analyze the effect of hyperbaric oxygen on newly formed bone in distracted areas surrounding the root of a moving tooth by histological and radiological analysis. It was hypothesized that the application of hyperbaric oxygen to a tooth moving into the distracted area would accelerate ossification and vascularization of newly formed bone in the distracted space. Design: Ten dogs were used. After creating a 10-mm-long bone defect, a bony segment was prepared and translocated into the defect area at a rate of 1 mm/d for 10 days. Following the distraction period, tooth movement was started and the dogs were divided into two groups. The HBO group received hyperbaric oxygen; whereas, the control group did not. At 150 days after tooth movement, the distracted area around the moving tooth was evaluated radiologically and histologically. Differences between groups were confirmed by a Mann-Whitney U test. Results: Trabecular bone density and cortical and subcortical bone areas measured by peripheral quantitative computed tomography in the HBO group were significantly higher than those in the control group. Histological observations revealed regenerated bone and blood vessels formation in the tension site of the moving tooth in the HBO group. The regenerated bone structure measured by bone histomorphometry was larger and more active in bone formation in the HBO group than in the control group. Conclusions: Applying hyperbaric oxygen to tooth movement into a distracted area appears to accelerate ossification and vascularization of regenerated bone in the that area.

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Keywords

10-mm-long bone
 
blood vessels formation
 
bone formation
 
bony segment
 
control group
 
defect area
 
distracted area
 
distraction period
 
HBO group
 
histological
 
Histological observations
 
histologically
 
Mann-Whitney U test
 
moving tooth
 
peripheral quantitative computed tomography
 
regenerated bone
 
regenerated bone structure
 
subcortical bone areas
 
tooth movement
 
Trabecular bone density