The effects of hyperbaric oxygen on tooth movement into the regenerated area after distraction osteogenesis.
ABSTRACT Abstract Objective: To analyze the effect of hyperbaric oxygen on newly formed bone in distracted areas surrounding the root of a moving tooth by histological and radiological analysis. It was hypothesized that the application of hyperbaric oxygen to a tooth moving into the distracted area would accelerate ossification and vascularization of newly formed bone in the distracted space. Design: Ten dogs were used. After creating a 10-mm-long bone defect, a bony segment was prepared and translocated into the defect area at a rate of 1 mm/d for 10 days. Following the distraction period, tooth movement was started and the dogs were divided into two groups. The HBO group received hyperbaric oxygen; whereas, the control group did not. At 150 days after tooth movement, the distracted area around the moving tooth was evaluated radiologically and histologically. Differences between groups were confirmed by a Mann-Whitney U test. Results: Trabecular bone density and cortical and subcortical bone areas measured by peripheral quantitative computed tomography in the HBO group were significantly higher than those in the control group. Histological observations revealed regenerated bone and blood vessels formation in the tension site of the moving tooth in the HBO group. The regenerated bone structure measured by bone histomorphometry was larger and more active in bone formation in the HBO group than in the control group. Conclusions: Applying hyperbaric oxygen to tooth movement into a distracted area appears to accelerate ossification and vascularization of regenerated bone in the that area.
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ABSTRACT: The inflammatory process is complex and the role of free radicals and antioxidants can be found in each part of it, such as the hemodynamic and permeability changes, the metabolism, and the function of the cells involved in the course of events. The main purpose of the present review is to mention the most common inflammatory processes in animals, the role of free radical formation in these, and the use of antioxidants against their detrimental effects. As with severely increased oxidative stress, decreased free radical formation can cause severe diseases. Hyperbaric oxygen gives an option to overcome the disorders caused by decreased oxidative stress response which is important in the bacterial killing mechanism and wound healing. Endotoxemia, systemic inflammatory response syndrome, in its complexity causes severe deterioration of the organism due to oxidative stress. Various antioxidants can be used to prevent the severity, such as superoxide dismutase (SOD), alpha-tocopherol, glutathione and its precursors, ascorbic acid, adenosine, lactoferrin, and carotenoids, thiols, ebselen, xanthine oxidase inhibitors, inhibitors of phagocyte function, iron ion chelators, and probucol, N-acetylcysteine, and 21-aminosteroids.Among pulmonary and other airway inflammatory diseases recurrent airway obstruction of horses causes severe oxidative damage. Apart from the well-known antioxidants, it seems that another antioxidant taurine, via N-chlorotaurine formation may protect the lung from oxidant-induced injury. This session contains more data of oxidative stress and possible antioxidant therapeutic advances in selective animal inflammatory diseases, such as kidney disease, gingivitis, uveitis, cataract, dermatitis, osteoarthritis, synovitis, pancreatitis, hepatitis, colitis and giardiasis, encephalopathy, neuritis and spinal cord injury, and bovine mastitis. KeywordsColitis-Gingivitis-Hepatitis-Hyperbaric oxygen therapy-Inflammation-Mastitis-Neuritis and spinal chord injury-Osteoarthritis-Pancreatitis-Recurrent airway obstruction-Synovitis-Systemic inflammatory response syndrome03/2011: pages 19-50;