[Show abstract][Hide abstract] ABSTRACT: This work describes a best-of-breed approach to traceability, in which the return-on-investment of the requirements traceability effort is maximized through the strategic deployment of a heterogeneous set of traceability techniques. This contrasts with typical traceability practices that tend to utilize a single technique such as a matrix or tool embedded into a requirements management package even though it may not provide the optimal solution for the traceability needs of a diverse set of requirements. The proposed solution, named TraCS (traceability for complex systems), defines project level trace strategies for categories of requirements and establishes links strategically in order to optimize returns of the traceability effort and minimize the risk inherent to software evolution. The paper provides a rationale for heterogeneous traceability, describes an extensible traceability framework, and then defines the process for establishing project level trace strategies. It concludes with an example drawn from a system to control chemical reactions at a catalyst plant.
[Show abstract][Hide abstract] ABSTRACT: The palm Euterpe oleracea Martius (acai) has been acclaimed to have a wide range of health-promoting and therapeutic benefits due to its reportedly high levels of antioxidants. Acai has a history of use as a medicinal plant and as a staple food in many parts of Brazil. Traditionally, it has been used to treat fevers, skin complications, digestive disorders and parasitic infections. Acai has also been of great economic importance in Brazil. In recent years, acai berry has been advertised widely, for example, via the Internet. This is based to a relatively high content of polyphenols, which in turn has been linked to a range of reported (mostly in vitro) antioxidant, anti-inflammatory, antiproliferative and cardioprotective properties. This review highlights the scientific knowledge about its phytochemistry and pharmacology (and its limitations). In vitro and in vivo studies have been assessed in order to determine the therapeutic potential of acai. Since there have been very limited studies the results are mostly inconclusive. Acai demonstrates promising potential with regard to antiproliferative activity and cardioprotection but further studies are required. Claims about alleged health benefits can generally only be substantiated to a very limited degree. Strategies need to be developed in order to prioritise lesser studied 'novel' herbal, medicines or nutraceuticals generally distributed/popularised via the Internet and to assess the benefits and risks of such products which also allows for the evaluation of the claims made.
[Show abstract][Hide abstract] ABSTRACT: Açai (Euterpe oleracea Mart.) has recently emerged as a promising source of natural antioxidants. Because increased oxidative stress and impaired antioxidant defense mechanisms are important factors in the development of diabetic complications and many health claims have been reported for açai, the present study was undertaken to evaluate the possible protective effects of açai on the production of reactive oxygen species by neutrophils and on the liver antioxidant defense system in control and streptozotocin-induced diabetic rats. Diet supplementation with 2% açai was found to increase mRNA levels for gamma-glutamylcysteine synthetase and glutathione peroxidase in liver tissue and to decrease reactive oxygen species production by neutrophils. Compared to control animals, diabetic rats exhibited lower levels of mRNA coding for Zn-superoxide dismutase, glutathione peroxidase and gamma-glutamylcysteine synthetase and higher levels of reactive oxygen species production by neutrophils, thiobarbituric acid-reactive substances and carbonyl proteins in hepatic tissues. Although açai supplementation was not effective in restore gene expression of antioxidant enzymes in diabetic rats, it showed a protective effect, decreasing thiobarbituric acid-reactive substances levels and increasing reduced glutathione content in the liver. These findings suggest that açai can modulate reactive oxygen species production by neutrophils and that it has a significant favorable effect on the liver antioxidant defense system under fisiological conditions of oxidative stress and partially revert deleterious effects of diabetes in the liver.
Journal of Clinical Biochemistry and Nutrition 11/2011; 49(3):188-94. DOI:10.3164/jcbn.11-02 · 2.29 Impact Factor
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