Glanzmann thrombasthenia: An update

Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Clinica chimica acta; international journal of clinical chemistry (Impact Factor: 2.82). 10/2009; 411(1-2):1-6. DOI: 10.1016/j.cca.2009.10.016
Source: PubMed


Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder characterized by qualitative or quantitative abnormalities of the platelet membrane glycoprotein (GP) IIb/IIIa. Physiologically, this platelet receptor normally binds several adhesive plasma proteins, and this facilitates attachment and aggregation of platelets to ensure thrombus formation at sites of vascular injury. The lack of resultant platelet aggregation in GT leads to mucocutaneous bleeding whose manifestation may be clinically variable, ranging from easy bruising to severe and potentially life-threatening hemorrhages. In this review we discuss the main characteristics of GT, focusing on molecular defects, diagnostic evaluation and treatment strategies.

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    • "Dental extractions and other invasive procedures are frequently complicated by excessive bleeding. Platelet aggregation in the presence of ristocetin and absence of platelet aggregation in the presence of ADP, epinephrine, collagen and thrombin will confirm the diagnosis of GT.[14] Flow cytometry can also be used in GT to detect the presence of the IIb-IIIa GP complex, GPIIb (CD41), GPIIIa (CD61) and fibrinogen using monoclonal antibodies.[15] "
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