Article

Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis.

Department of Neurology and Neurosurgery, Division of Neurology, Universidade Federal de São Paulo/UNIFESP, São Paulo, Brazil.
Epilepsy & Behavior (impact factor: 2.34). 11/2009; 16(3):447-53. DOI:10.1016/j.yebeh.2009.08.032 pp.447-53
Source: PubMed

ABSTRACT The aim of the study described here was to examine the relationship between memory function, proton magnetic resonance spectroscopy ((1)H-MRS) abnormalities, and interictal epileptiform discharge (IED) lateralization in patients with temporal lobe epilepsy (TLE) related to unilateral mesial temporal sclerosis.
We assessed performance on tests of memory function and intelligence quotient (IQ) in 29 right-handed outpatients and 24 controls. IEDs were assessed on 30-minute-awake and 30-minute-sleep EEG samples. Patients had (1)H-MRS at 1.5 T.
There was a negative correlation between IQ (P=0.031) and Rey Auditory Verbal Learning Test results (P=0.022) and epilepsy duration; between(1)H-MRS findings and epilepsy duration (P=0.027); and between N-acetylaspartate (NAA) levels and IEDs (P=0.006) in contralateral mesial temporal structures in the left MTS group. (1)H-MRS findings, IEDs, and verbal function were correlated.
These findings suggest that IEDs and NAA/(Cho+Cr) ratios reflecting neural metabolism are closely related to verbal memory function in mesial temporal sclerosis. Higher interictal activity on the EEG was associated with a decline in total NAA in contralateral mesial temporal structures.

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Keywords

1)H-MRS findings
 
24 controls
 
29 right-handed outpatients
 
30-minute-sleep EEG samples
 
between(1)H-MRS findings
 
contralateral mesial temporal structures
 
epilepsy duration
 
Higher interictal activity
 
intelligence quotient
 
interictal epileptiform discharge
 
left MTS group
 
memory function
 
mesial temporal sclerosis
 
patients
 
proton magnetic resonance spectroscopy
 
temporal lobe epilepsy
 
total NAA
 
unilateral mesial temporal sclerosis
 
verbal function
 
verbal memory function