Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study

Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
Schizophrenia Research (Impact Factor: 3.92). 10/2009; 117(1):13-20. DOI: 10.1016/j.schres.2009.09.030
Source: PubMed


Recently, a great deal of interest has arisen in resting state fMRI as a measure of tonic brain function in clinical populations. Most studies have focused on the examination of temporal correlation between resting state fMRI low-frequency oscillations (LFOs). Studies on the amplitudes of these low-frequency oscillations are rarely reported. Here, we used amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; the relative amplitude that resides in the low frequencies) to examine the amplitude of LFO in schizophrenia. Twenty-six healthy controls and 29 patients with schizophrenia or schizoaffective disorder participated. Our findings show that patients showed reduced low-frequency amplitude in proportion to the total frequency band investigated (i.e., fALFF) in the lingual gyrus, left cuneus, left insula/superior temporal gyrus, and right caudate and increased fALFF in the medial prefrontal cortex and the right parahippocampal gyrus. ALFF was reduced in patients in the lingual gyrus, cuneus, and precuneus and increased in the left parahippocampal gyrus. These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed.

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    • "ALFF has been widely used to investigate abnormal brain fluctuations and regional spontaneous activity in different neuropsychiatric disorders. More detailed information and examples can be found in previous studies (Hoptman et al., 2010; Liu et al., 2012; Zou et al., 2008). "
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    • "Previous studies have found that abnormalities in several neuropsychiatric disorders are frequency sensitive. It is reported that amnestic mild cognitive impairment (aMCI) patients had greater decreases in low frequency oscillation amplitude in the PCC/precuneus and parahippocampal gyrus in Slow-5 band than in Slow-4 band (Han et al., 2011), and patients with schizophrenia had widespread abnormalities of low frequency oscillation amplitudes in the Slow-4 frequency band (Hoptman et al., 2010). Another study indicated greater diagnostic information for children with attention-deficit hyperactivity disorder in the Slow-4 band rather than other bands (Di Martino et al., 2009). "
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    • "For those reasons, it may be more informative to examine low frequency oscillations (LFO), which can be considered a potential index of spontaneous fluctuations at rest. Previous fMRI studies investigating LFO amplitudes have reported meaningful differences among brain regions and clinical populations (Hoptman et al., 2010; Zang et al., 2007). An approach called amplitude of low frequency fluctuations (ALFF) provides a measure of regional changes in neural activity in a resting state scan (Zang et al., 2007). "
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