Article

Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study

Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
Schizophrenia Research (Impact Factor: 4.43). 10/2009; 117(1):13-20. DOI: 10.1016/j.schres.2009.09.030
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ABSTRACT Recently, a great deal of interest has arisen in resting state fMRI as a measure of tonic brain function in clinical populations. Most studies have focused on the examination of temporal correlation between resting state fMRI low-frequency oscillations (LFOs). Studies on the amplitudes of these low-frequency oscillations are rarely reported. Here, we used amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; the relative amplitude that resides in the low frequencies) to examine the amplitude of LFO in schizophrenia. Twenty-six healthy controls and 29 patients with schizophrenia or schizoaffective disorder participated. Our findings show that patients showed reduced low-frequency amplitude in proportion to the total frequency band investigated (i.e., fALFF) in the lingual gyrus, left cuneus, left insula/superior temporal gyrus, and right caudate and increased fALFF in the medial prefrontal cortex and the right parahippocampal gyrus. ALFF was reduced in patients in the lingual gyrus, cuneus, and precuneus and increased in the left parahippocampal gyrus. These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed.

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    • "For those reasons, it may be more informative to examine low frequency oscillations (LFO), which can be considered a potential index of spontaneous fluctuations at rest. Previous fMRI studies investigating LFO amplitudes have reported meaningful differences among brain regions and clinical populations (Hoptman et al., 2010; Zang et al., 2007). An approach called amplitude of low frequency fluctuations (ALFF) provides a measure of regional changes in neural activity in a resting state scan (Zang et al., 2007). "
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    • "The amplitude of low-frequency fluctuations (ALFF) of the BOLD signal, an index that measures the total power of a given time course within a specific frequency range (0.01–0.08 Hz) (Zang et al., 2007), was employed to compare the resting-state brain activity before and after body–mind relaxation meditation induction. Due to its high temporal stability (Kublbock et al., 2014) and test–retest reliability (Zuo and Xing, 2014), ALFF has been suggested as a biologically meaningful index for assessing the altered neural activity associated with behavioral performance or psychiatric disorders (Hoptman et al., 2010; Yan et al., 2009; Yang et al., 2007). Functional connectivity (FC) is another widely-used fMRI data analysis method, which measures the temporal correlation between different brain regions. "
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    • "As an alternative index to measure intrinsic brain responses at the baseline state, amplitude of low-frequency fluctuation (ALFF) reflects the intensity of regional neuronal activity (Biswal et al., 1995). This algorithm has been used as an effective method in assessing the altered neural activity of various neurological or psychiatric disorders, such as Alzheimer3s disease, epilepsy, hepatic encephalopathy and schizophrenia (Chen et al., 2012; Hoptman et al., 2010; Wang et al., 2011; Zhang et al., 2010). Lv et al. found significant increased ALFF in bilateral precuneus and inferior frontal gyrus and decreased ALFF in multiple occipital areas of pulsatile tinnitus patients (Han et al., 2014). "
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