Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study

Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
Schizophrenia Research (Impact Factor: 4.43). 10/2009; 117(1):13-20. DOI: 10.1016/j.schres.2009.09.030
Source: PubMed

ABSTRACT Recently, a great deal of interest has arisen in resting state fMRI as a measure of tonic brain function in clinical populations. Most studies have focused on the examination of temporal correlation between resting state fMRI low-frequency oscillations (LFOs). Studies on the amplitudes of these low-frequency oscillations are rarely reported. Here, we used amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; the relative amplitude that resides in the low frequencies) to examine the amplitude of LFO in schizophrenia. Twenty-six healthy controls and 29 patients with schizophrenia or schizoaffective disorder participated. Our findings show that patients showed reduced low-frequency amplitude in proportion to the total frequency band investigated (i.e., fALFF) in the lingual gyrus, left cuneus, left insula/superior temporal gyrus, and right caudate and increased fALFF in the medial prefrontal cortex and the right parahippocampal gyrus. ALFF was reduced in patients in the lingual gyrus, cuneus, and precuneus and increased in the left parahippocampal gyrus. These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed.

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Available from: Matthew Hoptman, Aug 31, 2015
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    • "For those reasons, it may be more informative to examine low frequency oscillations (LFO), which can be considered a potential index of spontaneous fluctuations at rest. Previous fMRI studies investigating LFO amplitudes have reported meaningful differences among brain regions and clinical populations (Hoptman et al., 2010; Zang et al., 2007). An approach called amplitude of low frequency fluctuations (ALFF) provides a measure of regional changes in neural activity in a resting state scan (Zang et al., 2007). "
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    Drug and Alcohol Dependence 05/2015; 103. DOI:10.1016/j.drugalcdep.2015.04.019 · 3.28 Impact Factor
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    • "The amplitude of low-frequency fluctuations (ALFF) of the BOLD signal, an index that measures the total power of a given time course within a specific frequency range (0.01–0.08 Hz) (Zang et al., 2007), was employed to compare the resting-state brain activity before and after body–mind relaxation meditation induction. Due to its high temporal stability (Kublbock et al., 2014) and test–retest reliability (Zuo and Xing, 2014), ALFF has been suggested as a biologically meaningful index for assessing the altered neural activity associated with behavioral performance or psychiatric disorders (Hoptman et al., 2010; Yan et al., 2009; Yang et al., 2007). Functional connectivity (FC) is another widely-used fMRI data analysis method, which measures the temporal correlation between different brain regions. "
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    ABSTRACT: Meditation has been increasingly evaluated as an important complementary therapeutic tool for the treatment of depression. The present study employed resting-state functional magnetic resonance imaging (rs-fMRI) to examine the effect of body-mind relaxation meditation induction (BMRMI) on the brain activity of depressed patients and to investigate possible mechanisms of action for this complex intervention. 21 major depressive disorder patients (MDDs) and 24 age and gender-matched healthy controls (HCs) received rs-fMRI scans at baseline and after listening to a selection of audio designed to induce body-mind relaxation meditation. The rs-fMRI data were analyzed using Matlab toolbox to obtain the amplitude of low-frequency fluctuations (ALFF) of the BOLD signal for the whole brain. A mixed-design repeated measures analysis of variance (ANOVA) was performed on the whole brain to find which brain regions were affected by the BMRMI. An additional functional connectivity analysis was used to identify any atypical connection patterns after the BMRMI. After the BMRMI experience, both the MDDs and HCs showed decreased ALFF values in the bilateral frontal pole (BA10). Additionally, increased functional connectivity from the right dorsal medial prefrontal cortex (dmPFC) to the left dorsal lateral prefrontal cortex (dlPFC) and the left lateral orbitofrontal cortex (OFC) was identified only in the MDDs after the BMRMI. In order to exclude the impact of other events on the participants׳ brain activity, the Hamilton Rating Scales for Depression (HDRS) was not measured after the body-mind relaxation induction. Our findings support the hypothesis that body-mind relaxation meditation induction may regulate the activities of the prefrontal cortex and thus may have the potential to help patients construct reappraisal strategies that can modulate the brain activity in multiple emotion-processing systems. Copyright © 2015 Elsevier B.V. All rights reserved.
    Journal of Affective Disorders 04/2015; 183. DOI:10.1016/j.jad.2015.04.030 · 3.71 Impact Factor
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    • "As an alternative index to measure intrinsic brain responses at the baseline state, amplitude of low-frequency fluctuation (ALFF) reflects the intensity of regional neuronal activity (Biswal et al., 1995). This algorithm has been used as an effective method in assessing the altered neural activity of various neurological or psychiatric disorders, such as Alzheimer3s disease, epilepsy, hepatic encephalopathy and schizophrenia (Chen et al., 2012; Hoptman et al., 2010; Wang et al., 2011; Zhang et al., 2010). Lv et al. found significant increased ALFF in bilateral precuneus and inferior frontal gyrus and decreased ALFF in multiple occipital areas of pulsatile tinnitus patients (Han et al., 2014). "
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