Article

Mitochondria: A therapeutic target in neurodegeneration

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Biochimica et Biophysica Acta (Impact Factor: 4.66). 10/2009; 1802(1):212-20. DOI: 10.1016/j.bbadis.2009.10.007
Source: PubMed

ABSTRACT Mitochondrial dysfunction has long been associated with neurodegenerative disease. Therefore, mitochondrial protective agents represent a unique direction for the development of drug candidates that can modify the pathogenesis of neurodegeneration. This review discusses evidence showing that mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis. We also debate the potential therapeutic efficacy of metabolic antioxidants, mitochondria-directed antioxidants and Szeto-Schiller (SS) peptides. Since these compounds preferentially target mitochondria, a major source of oxidative damage, they are promising therapeutic candidates for neurodegenerative diseases. Furthermore, we will briefly discuss the novel action of the antihistamine drug Dimebon on mitochondria.

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Available from: George Perry, Jun 22, 2015
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