Assessing the validity of self-reported medication adherence among inner-city asthmatic adults: The Medication Adherence Report Scale for Asthma

Division of General Internal Medicine, Mount Sinai School of Medicine, New York, New York USA.
Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology (Impact Factor: 2.6). 10/2009; 103(4):325-31. DOI: 10.1016/S1081-1206(10)60532-7
Source: PubMed


A validated tool to assess adherence with inhaled corticosteroids (ICS) could help physicians and researchers determine whether poor asthma control is due to poor adherence or severe intrinsic asthma.
To assess the performance of the Medication Adherence Report Scale for Asthma (MARS-A), a 10-item, self-reported measure of adherence with ICS.
We interviewed 318 asthmatic adults receiving care at 2 inner-city clinics. Self-reported adherence with ICS was measured by MARS-A at baseline and 1 and 3 months. ICS adherence was measured electronically in 53 patients. Electronic adherence was the percentage of days patients used ICS. Patients with a mean MARS-A score of 4.5 or higher or with electronic adherence of more than 70% were defined as good adherers. We assessed internal validity (Cronbach alpha, test-retest correlations), criterion validity (associations between self-reported adherence and electronic adherence), and construct validity (correlating self-reported adherence with ICS beliefs).
The mean patient age was 47 years; 40% of patients were Hispanic, 40% were black, and 18% were white; 53% had prior asthma hospitalizations; and 70% had prior oral steroid use. Electronic substudy patients were similar to the rest of the cohort in age, sex, race, and asthma severity. MARS-A had good interitem correlation in English and Spanish (Cronbach alpha = 0.85 and 0.86, respectively) and good test-retest reliability (r = 0.65, P < .001). According to electronic measurements, patients used ICS 52% of days. Continuous MARS-A scores correlated with continuous electronic adherence (r = 0.42, P<.001), and dichotomized high self-reported adherence predicted high electronic adherence (odds ratio, 10.6; 95% confidence interval, 2.5-44.5; P < .001). Construct validity was good, with self-reported adherence higher in those saying daily ICS use was important and ICS were controller medications (P = .04).
MARS-A demonstrated good psychometric performance as a self-reported measure of adherence with ICS among English- and Spanish-speaking, low-income, minority patients with asthma.

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    • "For the cross-sectional study [BvdB] [20], 228 consecutive RA patients on DMARD therapy treated in the St. Maartenskliniek (a clinic specialized in rheumatology, rehabilitation and orthopedic surgery) completed questionnaires to examine the prevalence and possible determinants of non-adherence, including demographics , coping, beliefs about medication, satisfaction about medicine information, and physical functioning. Non-adherence was measured with the Compliance Questionnaire Rheumatology (CQR [21]) and the Medication Adherence Report Scale (MARS [22]). To gain in-depth insight into possible determinants of nonadherence , two patient focus groups led by two psychologists [WvL/BvdM] were organized to discuss necessity and concern beliefs about medication, the need for education, experienced social support, and practical barriers as perceived by RA patients. "
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