Article

Genetic Epidemiology of BMI and Body Mass Change From Adolescence to Young Adulthood

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Obesity (Impact Factor: 4.39). 10/2009; 18(7):1474-6. DOI: 10.1038/oby.2009.350
Source: PubMed

ABSTRACT The complex interplay between genes and environment affecting body mass gain over lifecycle periods of risk is not well understood. We use longitudinal sibling cohort data to examine the role of shared household environment, additive genetic, and shared genetic effects on BMI and BMI change. In the National Longitudinal Study of Adolescent Health, siblings and twin pairs sharing households for > or =10 years as adolescents (N = 5,524; mean = 16.5 +/- 1.7 years) were followed into young adulthood (N = 4,368; mean = 22.4 +/- 1.8 years). Using a variance component approach, we quantified genetic and household effects on BMI in siblings and nonsiblings sharing household environments over time. Adjusting for race, age, sex, and age-by-sex interaction, we detected a heritability of 0.43 +/- 0.05 for BMI change. Significant household effects were noted during the young adulthood period only (0.11 +/- 0.06). We find evidence for shared genetic effects between BMI and BMI change during adolescence (genetic correlation (rho(G)) = 0.61 +/- 0.03) and young adulthood (rho(G) = 0.23 +/- 0.06). Our findings support a complex etiology of BMI and BMI change.

Download full-text

Full-text

Available from: Mariaelisa Graff, Sep 01, 2015
0 Followers
 · 
122 Views
 · 
48 Downloads
  • Source
    • "We adjusted for the following individual characteristics: race, age, parental income (> $36,000), employment status, has any children, vehicle ownership ("has a car/motorcycle/van"). We included parental rather than the young adults' own education (> high school) because parental SES is shown to be a strong predictor of obesity and obesity-related behaviors [27-29] during the complex transitional stage of young adulthood [30,31] "
    [Show abstract] [Hide abstract]
    ABSTRACT: Recent studies suggest that neighborhood fast food restaurant availability is related to greater obesity, yet few studies have investigated whether neighborhood fast food restaurant availability promotes fast food consumption. Our aim was to estimate the effect of neighborhood fast food availability on frequency of fast food consumption in a national sample of young adults, a population at high risk for obesity. We used national data from U.S. young adults enrolled in wave III (2001-02; ages 18-28) of the National Longitudinal Study of Adolescent Health (n = 13,150). Urbanicity-stratified multivariate negative binomial regression models were used to examine cross-sectional associations between neighborhood fast food availability and individual-level self-reported fast food consumption frequency, controlling for individual and neighborhood characteristics. In adjusted analysis, fast food availability was not associated with weekly frequency of fast food consumption in non-urban or low- or high-density urban areas. Policies aiming to reduce neighborhood availability as a means to reduce fast food consumption among young adults may be unsuccessful. Consideration of fast food outlets near school or workplace locations, factors specific to more or less urban settings, and the role of individual lifestyle attitudes and preferences are needed in future research.
    BMC Public Health 07/2011; 11(1):543. DOI:10.1186/1471-2458-11-543 · 2.32 Impact Factor
  • Source
    Journal of the South Carolina Medical Association (1975) 108(5):124-7.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Obesity has been present in the human population at a low frequency for a very long time, most likely caused by rare monogenic or syndromic genetic disease. In the last few decades of the twentieth century and into the twenty-first, rates of obesity have greatly increased, initially in the USA, then in other Western industrialized countries until we now have a genuinely global epidemic. As evolution works on a far longer timescale than this, it has been concluded by many that genetics cannot possibly play a part in common obesity. However, many studies have demonstrated significant heritability for obesity-related traits, including body mass index (BMI), waist circumference (WC), waist–hip ratio (WHR), and eating behavior. One example would be twin studies of BMI, which have generated heritability estimates of 0.5–0.7 for this trait, commonly used to define clinical obesity. In this chapter we review the evidence for the crucial role of genetics in common clinical obesity within our obesogenic environment. We focus on the role of heritability in common obesity and provide an overview of both study designs and results for different obesity-related traits. KeywordsHeredity-Environment-Twin study-Adoption study-Heritability-Obesogenic-Linkage-Association-Case–control-Genome-wide
    12/2010: pages 25-52;
Show more