Lymphocyte-Depleted Thymic Remnants A Potential Diagnostic Pitfall in the Evaluation of Central Neck Dissections
ABSTRACT The head and neck region is a frequent site for potentially confusing incidental benign findings not related to the primary pathologic process and having no impact on patient prognosis. Several lesions are thymic in origin. We report 3 cases of lymphocyte-poor thymic remnants identified in central cervical (level VI) lymph node dissections for unrelated benign and malignant pathology. In each, the rests were nearly completely composed of bland epithelial cells with rare admixed lymphocytes. These cells were immunophenotypically similar to thymic epithelial cells, although they differed in the paucity of associated thymic lymphocytes and lack of Hassall corpuscles. Lymphocyte-depleted thymic remnants in the central cervical compartment are not well described in the literature. It is important to be aware of these and other benign inclusions to avoid making incorrect diagnoses of malignancy.
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ABSTRACT: The p63 gene, a member of the p53 family, is an epithelial marker expressed in embryonic ectoderm, breast myoepithelium, prostate, oral epithelium, epidermis, and urothelium. The DeltaN-p63 isoforms of p63, which are believed to behave as oncogenes, are expressed in squamous cell carcinoma, basal cell carcinoma, and transitional cell carcinoma. Only a few authors have looked for p63 expression in thymomas and normal thymus. We, therefore, thought of undergoing such a search by taking advantage of our archival material. We studied 66 cases of thymoma (1 type A, 8 type AB, 12 type B1, 19 type B2, 12 type B3, and 14 type C/thymic carcinoma) and 10 specimens of normal human thymus arranged in tissue microarrays. All thymomas (including thymic carcinomas) were positive for p63 regardless of type. Most of the epithelial cells of the normal thymus were also positive for this marker.American Journal of Clinical Pathology 04/2007; 127(3):415-20. DOI:10.1309/2GAYKPDDM85P2VEW · 3.01 Impact Factor
Article: Cervicomediastinal thymic cysts.[Show abstract] [Hide abstract]
ABSTRACT: Cervical thymic cysts are among the rarest congenital neck masses. They are probably more frequent than the number of cases reported as many of these lesions are asymptomatic and only discovered incidentally. The initial embryologic development of the thymus begins in the neck, followed by migration into the superior mediastinum. For this reason, extension of cervical thymic anomalies into the mediastinum is possible. Although it is the least common lateral cystic neck mass, it must be differentiated from other pediatric cystic neck masses, the majority of which are anomalies of the branchial system. Due to the possibility of mediastinal extension, the management of these lesions is different than other congenital neck masses. We report two cases of thymic anomalies with mediastinal extension and review the embryology, diagnosis, and management of cervicomediastinal thymic cysts.International Journal of Pediatric Otorhinolaryngology 04/1997; 39(2):139-46. DOI:10.1016/S0165-5876(96)01485-1 · 1.32 Impact Factor
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ABSTRACT: Heterotopic salivary gland tissue (HSGT) consists of salivary tissue outside of the major and minor salivary glands and typically presents as a draining sinus and/or asymptomatic nodule of the neck along the lower anterior sternocleidomastoid muscle. There are a limited number of case series exploring this rare entity. To further delineate the clinicopathologic characteristics of this lesion, we present 11 cases of HSGT in the neck, many with cutaneous involvement. Anatomic pathology files from Lifespan-affiliated hospitals (Rhode Island Hospital and Miriam Hospital) were retrospectively reviewed for all cases meeting criteria for HSGT from 1983 through 2005, and 11 patients were identified: 4 female and 7 male, ages 5 months to 64 years, with 8 patients younger than 18 years; 7 patients presented with a draining sinus. Of note, 8 of 11 cases occurred on the right side. In general, microscopic examination revealed mucinous and serous salivary glandular structures with an associated duct; no cytologic atypia was observed. All cases stained positive for smooth muscle actin and calponin, highlighting a myoepithelial layer similar to that seen in minor and major salivary glands. As in our series, most cases of cervical HSGT occur near the anterior sternocleidomastoid muscle with a right-sided predilection. Cases generally present by early childhood, although 3 cases in our series were diagnosed in adulthood. Although cancers arising in these lesions are fairly uncommon, most clinically apparent foci of HSGT are excised. This entity should be considered in the dermatologist's differential diagnostic considerations for a draining sinus and a lateral, especially right-sided, neck mass.Journal of the American Academy of Dermatology 03/2008; 58(2):251-6. DOI:10.1016/j.jaad.2007.11.009 · 5.00 Impact Factor