Left Ventricular Septal and Left Ventricular Apical Pacing Chronically Maintain Cardiac Contractile Coordination, Pump Function and Efficiency

Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands.
Circulation Arrhythmia and Electrophysiology (Impact Factor: 5.42). 10/2009; 2(5):571-9. DOI: 10.1161/CIRCEP.109.882910
Source: PubMed

ABSTRACT Conventional right ventricular (RV) apex pacing can lead to adverse clinical outcome associated with asynchronous activation and reduced left ventricular (LV) pump function. We investigated to what extent alternate RV (septum) and LV (septum, apex) pacing sites improve LV electric activation, mechanics, hemodynamic performance, and efficiency over 4 months of pacing.
After AV nodal ablation, mongrel dogs were randomized to receive 16 weeks of VDD pacing at the RV apex, RV septum, LV apex, or LV septum (transventricular septal approach). Electric activation maps (combined epicardial contact and endocardial noncontact) showed that RV apical and RV septal pacing induced significantly greater electric desynchronization than LV apical and LV septal pacing. RV apex and RV septal pacing also significantly increased mechanical dyssynchrony, discoordination (MRI tagging) and blood flow redistribution (microspheres) and reduced LV contractility, relaxation, and myocardial efficiency (stroke work/myocardial oxygen consumption). In contrast, LV apical and LV septal pacing did not significantly alter these parameters as compared with the values during intrinsic conduction. At 16 weeks, acute intrasubject comparison showed that single-site LV apical and LV septal pacing generally resulted in similar or better contractility, relaxation, and efficiency as compared with acute biventricular pacing.
Acute and chronic LV apical and LV septal pacing maintain regional cardiac mechanics, contractility, relaxation, and efficiency near native levels, whereas RV apical or RV septal pacing diminish these variables. Acute LV apical and LV septal pacing tend to maintain or improve contractility and efficiency compared with biventricular pacing.

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Available from: Marc Strik, Jul 18, 2015
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    • "have been equivocal regarding the chronic repercussions on LVEF (see Table 3). Our data are in agreement with the canine study by Mills et al. [26], in which no significant differences in LV contractility were found between apical and mid-septal RV pacing. Our study suggests that systolic function is significantly reduced when the lead is inadvertently placed in an anterior position instead of the mid-septum. "
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    • "In the animal study described by Mills et al (Mills et al, 2009), the lead was implanted in the RV midseptum, based solely on position and not optimizing the QRS complex. Surprisingly, none of the parameters investigated in this study (electric mapping, hemodynamic, regional strains, efficiency) showed a significant difference between RV apical and RV septal pacing. "
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