Inflammatory Myofibroblastic Tumors of the Abdomen as Mimickers of Malignancy: Imaging Features in Nine Children

Department of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Jongno-gu, Seoul 110-744, Korea.
American Journal of Roentgenology (Impact Factor: 2.73). 11/2009; 193(5):1419-24. DOI: 10.2214/AJR.09.2433
Source: PubMed


OBJECTIVE: The purpose of this study was to evaluate retrospectively the CT and sonographic features in nine children with pathologically proven inflammatory myofibroblastic tumors of the abdomen. CONCLUSION: Although inflammatory myofibroblastic tumors occur in various sites and the imaging characteristics are variable, tumors showed different imaging patterns that were dependent on the site at which the tumor had originated.

1 Follower
15 Reads
  • Source
    • "Intra-abdominal IMTs have clinical importance due to their relationship to malignancy. Intra-abdominal IMTs are difficult to distinguish preoperatively from other malignancies, such as sarcomas, lymphomas, and metastases [4]. IMTs were originally reported to be benign tumors, but can exhibit locally aggressive neoplastic processes and metastases similar to malignancies. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Inflammatory myofibroblastic tumor (IMT) is rare mesenchymal solid tumor that consists of proliferating myofibroblasts with an inflammatory infiltrate background. It has a very low prevalence in infants and occurs mainly in children and young adults. IMT are mainly located in the thoracic cavity, but intra-abdominal lesions are rare. IMT can exhibit locally aggressive neoplastic processes and metastases similar to malignancies, so, have clinical importance. Herein, we describe two infantile intra-abdominal IMT cases presenting with incidentally found palpable abdominal mass. A 4-month-old male infant had IMT at the ileal mesentery and a 5-month-old male infant had IMT at liver. Both cases were successfully treated by complete surgical resection without complication or recurrence. Considering the biological behavior of the intermediate type of neoplasm in IMT, we expect good survivals when achieving appropriate surgical resection without adjuvant therapy in infantile intra-abdominal IMT.
    06/2014; 17(2):116-20. DOI:10.5223/pghn.2014.17.2.116
  • Source
    • "The variate of terms used to describe this entity includes inflammatory pseudotumor, cellular inflammatory pseudotumor, plasma cell granuloma, inflammatory myofibrohistiocytic tumor, and more recently, inflammatory fibrosarcoma. This lesion consists of inflammatory cells and myofibroblastic spindle cells [1,2]. Although children constitute the majority of the reported cases of IMF tumor, this disease rarely appears in the adult. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Inflammatory myofibroblastic (IMF) tumor is a rare solid tumor that often affects children. IMF tumors occur primarily in the lung, but the tumor may affect any organ system with protean manifestations. A 22-year-old woman was evaluated for palpable low abdominal mass that had been increasing in size since two months prior. Abdominal computed tomography showed a lobulated, heterogeneous contrast enhancing soft tissue mass, 6.5 × 5.7 cm in size in the ileal mesentery. At surgery, the mass originated from the greater omentum laying in the pelvic cavity and was completely excised without tumor spillage. Histologically, the mass was a spindle cell lesion with severe atypism and some mitosis. Immunohistochemistry for anaplastic lymphoma kinase-1 revealed that the lesion was an IMF tumor. Because of its local invasiveness and its tendency to recur, this tumor can be confused with a soft tissue sarcoma. Increasing physician awareness of this entity should facilitate recognition of its clinical characteristics and laboratory findings.
    06/2012; 82(6):380-4. DOI:10.4174/jkss.2012.82.6.380
  • Source
    • "On CT they are variously described as homo-or heterogeneous hypervascular lesions showing moderate to intense enhancement. Calcification, haemorrhage and necrosis are reported in a few cases [4] . The top differentials include sarcoma, lymphoma, GIST, Castleman’s disease and all causes of peritoneal carcinomatosis in the case of multiple masses [5] . "
    [Show abstract] [Hide abstract]
    ABSTRACT: Inflammatory myofibroblastic tumour (IMFT) is a relatively uncommon neoplasm with unpredictable malignant potential known to occur anywhere in the body. IMFT involving the omentum is a very rare entity with less than 15 cases reported so far. We report a case of omental IMFT in a 15-year-old girl who presented with multiple peritoneal masses on imaging and the diagnosis was confirmed on histopathology. In addition to its uncommon location, its presentation as multiple masses is extremely uncommon. This uncommon presentation as multifocal masses needs to be distinguished from other causes of peritoneal carcinomatosis.
    Cancer Imaging 03/2011; 11(1):19-22. DOI:10.1102/1470-7330.2011.0005 · 2.07 Impact Factor
Show more


15 Reads
Available from