Article

Chemical constituents from the whole plant of Gaultheria itoana Hayata.

Department of Medical Technology, School of Medical and Health Science, Fooyin University, Kaohsiung 831, Taiwan.
Chemistry & Biodiversity (Impact Factor: 1.81). 10/2009; 6(10):1737-43. DOI: 10.1002/cbdv.200800270
Source: PubMed

ABSTRACT Two new diterpenoids, 14,18-dihydroxyabieta-8,11,13-trien-7-one (1) and 13-acetyl-14,18-dihydroxy-podocarpa-8,11,13-triene (2), together with eight known compounds, i.e., gaultheric acid (3), vanillic acid (4), 4-hydroxybenzoic acid (5), cinnamic acid (6), stearic acid (7), palmitic acid (8), beta-sitosterol (9), and stigmasterol (10), were isolated from the MeOH extract of the whole plant of Gaultheria itoana Hayata (Ericaceae). The structures of the new constituents were elucidated by spectroscopic methods (UV, IR, and 1D- and 2D-NMR) and by mass spectrometry (HR-ESI-MS). Among them, 1 and 2 were demonstrated to exhibit significant cytotoxic activity against the LNCaP cell line.

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