F-18-FDG Uptake in Lung, Breast, and Colon Cancers: Molecular Biology Correlates and Disease Characterization

Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Journal of Nuclear Medicine (Impact Factor: 6.16). 11/2009; 50(11):1820-7. DOI: 10.2967/jnumed.108.054098
Source: PubMed


It is hoped that in the not too distant future, noninvasive imaging-based molecular interrogation and characterization of tumors can improve our fundamental understanding of the dynamic biologic behavior of cancer. For example, the new dimension of diagnostic information that is provided by (18)F-FDG PET has led to improved clinical decision making and management changes in a substantial number of patients with cancer. In this context, the aim of this review is to bring together and summarize the current data on the correlation between the underlying molecular biology and the clinical observations of tumor (18)F-FDG accumulation in 3 major human cancers: lung, breast, and colon.

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Available from: Hossein Jadvar, Feb 19, 2014
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    • "Since then, this " aerobic glycolysis " is known as the " Warburg effect. " Because glycolysis is far less efficient for ATP production compared to mitochondrial oxidative phosphorylation , it is usually associated with marked increases in glucose uptake and consumption [23], a phenomenon clinically exploited to visualize cancer using the glucose similar 18-fluorodeoxyglucose by positron electron tomography [24]. The preference of cancers for aerobic glycolysis, over the more energy-efficient oxidative phosphorylation pathway, has many advantages for cancer. "
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    BioMed Research International 01/2015; 2015(2). DOI:10.1155/2015/137097 · 3.17 Impact Factor
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    • "Increased glucose uptake is a widely described phenomenon in cancer cells, being the rationale behind the whole-body non-invasive positron emission imaging technique, using 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET). This technique is useful in the diagnosis and prognosis of breast cancer, especially regarding the detection of distant metastases, and recurrent disease as well as in monitoring response to therapy (Jadvar et al. 2009). This increased uptake of glucose, especially through glucose transporter 1 (GLUT1), is a consequence of an increased glycolytic metabolism that generates acids inside the cell. "
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    • "In contrast, cancer cells primarily derive energy from glucose via glycolysis to lactic acid, even under highly aerobic conditions, a property first observed by Otto Warburg 1. This ‘aerobic glycolysis’, also known as the ‘Warburg effect’ 2, is much less energy-efficient than the oxidative phosphorylation pathway 3. It is usually accompanied by marked increases in glucose uptake and consumption 4, a phenomenon commonly exploited in tumour imaging using 18-fluorodeoxyglucose positron electron tomography 5. In addition, cancer cells derive energy from up-regulated non-glucose-dependent pathways, such as increased glutaminolysis under aerobic conditions 2,6,7. "
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