Conference Proceeding

Invasive confirmation of the human ventricular activation sequence as computed from body surface potentials

Nijmegen Univ.
11/1992; DOI:10.1109/CIC.1992.269505 ISBN: 0-8186-3552-5 pp.427 - 430 In proceeding of: Computers in Cardiology 1992. Proceedings.
Source: IEEE Xplore

ABSTRACT The authors recorded body surface potential maps (BSPMs) of a
patient undergoing a catheterization. During this catheterization the
heart was paced on a fixed location in the right ventricle. They then
used an inverse procedure, which was developed previously, to determine
the isochrones of ventricular activation noninvasively, from the
measured BSPMs. The computed activation sequence for the paced heartbeat
was in complete accordance with what was known invasively. It reflected
the spreading of a single wavefront starting at the exact site of pacing
in the right ventricle

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    Article: Use of body surface potential maps for model-based assessment of local pathological changes in the heart
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    ABSTRACT: High resolution body surface potential maps and an equivalent current dipole model of the cardiac generator were used to assess the heart state in two abnormal conditions: WPW syndrome with single accessory pathway and local ventricular ischemia. Results of a simulation study and experimental verification of the method for both cardiologic abnormalities are presented. Single accessory pathway in WPW syndrome was simulated as initial ventricular activation at the atrio-ventricular ring. Using a current dipole model of the cardiac generator, the locus of arrhythmogenic tissue was assessed with a mean error of 11 mm. Experimental localization of the accessory pathway in a WPW patient was in good agreement with the invasively obtained site. Local repolarization changes were simulated as shortening of the myocytes action potentials in three regions typical for stenosis of main coronary arteries. Using surface QRST integral maps and dipolar source model, small subendocardial and subepicardial lesions of myocardium were inversely located with a mean error of 9 mm and larger transmural lesions with a considerable mean error of 17 mm. Extent and prevalence of subepicardial or subendocardial type of the lesion were reflected in the dipole moment and orientation. In experimental verification of the method, in 7 of 8 patients that underwent PCI of a single vessel, estimated equivalent current dipole position matched well the treated vessel. The results suggest that diagnostic interpretation of body surface potential maps based on dipolar source model could be a useful tool to assess local pathological changes in the heart. Key words: body surface potential mapping, noninvasive cardiac diagnostics, equivalent current dipole model of the cardiac generator, ECG simulation.
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