Article

Atypical Cholecystitis after Bone Marrow Transplantation : Gallbladder Wall Thickening due to Cyclosporine A

DOI:0513-1812, AA00594272, The bulletin of the Yamaguchi Medical School, 51, 3-4, 51, 53, 2004-12
Source: OAI

ABSTRACT A 16-year-old Japanese male with acute mixed lineage leukemia in the second remission underwent allogeneic bone mallow transplantation from a HLA-identical sibling donor. Atypical choleccystitis developed three weeks after transplantation. Abdominal ultrasound examination revealed maked thickening of the gallbladder wall without biliary sludge or gallstones. Cholecystitis was treated by the cessation of cycloporine A three days after symptoms development. To our knowledge, this is the first report of a patient with cyclosporine A induced cholecystitis, that may have been due to direct injury to the gallbladder wall and not a cholestatic mechanism.

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Keywords

16-year-old Japanese male
 
Abdominal ultrasound examination
 
acute mixed lineage leukemia
 
allogeneic bone mallow transplantation
 
Atypical choleccystitis
 
biliary sludge
 
cessation
 
direct injury
 
first report
 
induced cholecystitis
 
symptoms development
 
three days
 

Yoshitaka Nakamori