A Peripheral Nerve Information Transducer for Amputees: Long-Term Multichannel Recordings from Rabbit Peripheral Nerves
ABSTRACT A micromachined silicon technology is being developed for the purpose of sensing information from the stumps of amputated mammalian peripheral nerves. Information on long-term biocompatibility, anatomy, and physiology related to the structural design of this sensor is presented. Pertinent materials, fabrication, and surgical implantation issues are discussed. Noise, signal amplitude, and receptive field are considered as the prime determinants of the design of an appropriate electrode contact geometry for the structure. The selectivity of the device is also discussed in terms of the fine structure of the regenerated nerve. Examples of waveforms recorded from rabbit peripheral nerves using this sensor are presented and discussed in terms of electrical and physiological parameters. Possible use of the sensor as a source for a binary code suitable for communication of information to a computer is presented along with discussion of the limitations of the current technology and possible future applications.
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ABSTRACT: Low pressure chemical vapor deposition (LPCVD) and plasma enhanced chemical vapor deposition (PECVD) silicon oxide and silicon nitride films were implanted subcutaneously in a rat model to study in vivo behavior of the films. Silicon chips coated with the films of interest were implanted for up to one year, and film thickness was evaluated by spectrophotometry and sectioning. Dissolution rates were estimated to be 0.33 nm/day for LPCVD silicon nitride, 2.0 nm/day for PECVD silicon nitride, and 3.5 nm/day for PECVD silicon oxide. A similar PECVD silicon oxide dissolution rate was observed on a silicon oxide / silicon nitride / silicon oxide stack that was sectioned by focused ion beam etching. These results provide a biostability reference for designing implantable microfabricated devices that feature exposed ceramic films.
Engineering in Medicine and Biology Society, 1993. Proceedings of the 15th Annual International Conference of the IEEE; 01/1993
BHARATIYA VIGYAN SAMMELAN (BVS),, Lovely Professional University, Jalandhar; 10/2012