Analysis of Information Transmission
ABSTRACT Hippocampal region CA1 seems from comparative studies to be particularly important in the primate brain, in addition to being crucial to memory function. Thus, it is an extremely appropriate place to begin a quantitative investigation of the information representation and transmission capabilities of cerebral neural networks. In this study, a mathematical model of the Schaffer collateral projection from CA3 to CA1 is described. From the model, the amount of information that can be conveyed by the Schaffer collaterals is calculated, i.e., the information that a pattern of firing in CA1 conveys about a pattern of firing in CA3, because of the connections between them. The calculation is performed analytically for an arbitrary probability distribution describing the pattern of CA3 firing and then solved numerically for particular input distributions. The effect of a number of issues on the information conveyed is examined.