Article

Carnitina, colina e fosfatidilcolina como nutrientes reguladores do metabolismo de lipídios e determinantes do desempenho esportivo

Lecturas: Educación física y deportes, ISSN 1514-3465, Nº. 108, 2007 01/2007;
Source: OAI

ABSTRACT A carnitina, colina e fosfatidilcolina são compostos intermediários essenciais para o metabolismo de lipídios. A deficiência destes pode afetar o catabolismo de lipídios, entretanto não está claro se a suplementação resultaria em maior catabolismo de lipídios, o que por sua vez poderia resultar em perda de massa adiposa. Este trabalho teve por objetivo, através de uma revisão sistematizada, discutir os resultados de estudos que apontem as relações da carnitina, colina e fosfatidilcolina no metabolismo de lipídios e desempenho desportivo. A ação da carnitina como potencializador do catabolismo de lipídios permanece controversa, entretanto sua ação antioxidante é comprovada. A colina é um composto essencial a saúde corporal, entretanto a recomendação diária pode ser conseguida em diversos alimentos. A fosfatidilcolina desempenha um importante papel na absorção intestinal de lipídios, sendo encontrada em diversas fontes alimentares.

0 Bookmarks
 · 
57 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: A study was designed to examine the hypolipidemic effect of L-carnitine treatment (4 weeks, 170 mg/kg/d) in rabbits fed a high fat diet (5% corn oil/0.5% cholesterol, w/w). Eight weeks of exposure to the high fat diet significantly increased plasma total cholesterol and triglycerides. VLDL associated triglycerides, cholesterol, apo-B, and total protein were also significantly increased with the diet. There was no change in HDL-cholesterol levels. Plasma concentration of carnitine (free, acyl, and total) all increased significantly with the high fat diet. The content of free, short-chain, and total carnitine were decreased in the liver whereas the content of long-chain acylcarnitines was increased. The diet generated a significant steatosis within the livers of these animals. Four weeks of treatment of L-carnitine reduced the extent of the liver steatosis and significantly decreased plasma total cholesterol, triglycerides, VLDL associated triglycerides, cholesterol, and total protein. HDL-cholesterol levels were unaffected by the treatment. All plasma fractions of carnitine (free, acetyl, acyl, and total) were significantly increased above those levels seen after 8 weeks of the high fat diet alone. The content of liver carnitine and its esters was normalized following treatment. The high fat diet decreased liver HMG-CoA reductase activity and increased the activities of 7-alpha-hydroxylase and acylcholesterol acyltransferase (ACAT). L-Carnitine treatment blunted the magnitude of the diet induced increase in 7 alpha-hydroxylase activity, yet overall the activity still remained elevated relative to controls. ACAT activity increased (1.5 times) with the high fat diet and increased further (4.5 times) following carnitine treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
    Metabolism 01/1988; 36(12):1192-6. · 3.10 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Lipid peroxides are considered to be the initiation factor for atherosclerosis. Present study depicts that L-carnitine treatment (300 mg/kg body weight/day) for 7 and 14 days caused significant reduction in the tissue lipid peroxidations. It also shows marked improvement in the antioxidant status. By this way carnitine maintain the normal function of the cells.
    The Journal of nutritional biochemistry 06/2001; 12(5):254-257. · 4.29 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The effect of l-carnitine on lipid peroxidation and antioxidant status has been studied in blood, liver, and kidney of young and aged rats. In the aged rats, level of lipid peroxidation was considerably high, while the antioxidants superoxide dismutase, catalase, glutathione peroxidase, vitamin C, and vitamin E reduced glutathione, and total thiols were low. The l-carnitine was administered by i.p. injection (300 mg/kg body weight/day) for 7, 14, and 21 days. Supplementation of aged rats with l-carnitine demonstrated a time-dependent normalization of abnormally elevated lipid peroxides and of subnormal antioxidant status. Carnitine administration to young rats has brought reduction in lipid peroxidation and elevation in glutathione peroxidase activity and ascorbic acid content. From our observations we conclude that as carnitine is very effective in normalizing age-associated alterations, it can be implemented in the aged to minimize age-associated disorders where free radicals are the major cause.
    Journal of Nutritional Biochemistry - J NUTR BIOCHEM. 01/1998; 9(10):575-581.

Full-text (2 Sources)

View
20 Downloads
Available from
May 20, 2014