Carbapenem-resistant enterobacteriaceae containing New Delhi metallo-beta-lactamase in two patients - Rhode Island, March 2012
Morbidity and Mortality Weekly Report 06/2012; 61(24):446-448.
Available from: Bijie Bie
- "NDM-1 was initially discovered in India, first reported by UK scientists, and has received plenty of attention in India and the UK, and is emerging in the USA. By September 2011, there were 143 NDM-1 cases in India, 88 cases in the UK (Health Protection Agency, 2011), and 13 cases in the USA (Hardy et al., 2012). 2. Fung et al. (2011) investigated an additional risk characteristic in their study of news coverage of avian flu: catastrophic potential. "
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ABSTRACT: Marrying the psychometric paradigm with the community structure theory, this paper examines the coverage of a superbug (NDM-1) in newspapers in India, the UK, and the USA. It identifies several community structure characteristics: level of vested economic interest, level of health care available, and size of health care stakeholders as factors influencing how risks of NDM-1 are portrayed in terms of the level of dread, controllability, familiarity, and uncertainty. The finding provides baseline data for the scientific community and public health professionals in creating more effective messages to inform the public about the risks of superbugs.
Asian Journal of Communication 09/2015; DOI:10.1080/01292986.2015.1076867 · 0.41 Impact Factor
Available from: Jan Kluytmans
Clinical Infectious Diseases 09/2012; 55(11). DOI:10.1093/cid/cis776 · 8.89 Impact Factor
Available from: Roberto G Melano
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New Delhi metallo-ß-lactamase (NDM) has emerged worldwide in clinically relevant gram-negative bacteria. We report an outbreak of NDM-producing Klebsiella pneumoniae in patients with no prior travel history to endemic regions.
Five NDM-1-producing K. pneumoniae colonizing and/or clinically infecting patients in a community tertiary hospital were detected between October and November 2011. NDM-1-producing Enterobacteriaceae (K. pneumoniae and Escherichia coli) were clinically and epidemiologically characterized, including susceptibility profiles, molecular typing, and molecular characterization of plasmids and resistant determinants.
Five patients were identified carrying NDM-1-producing K. pneumoniae, all of them epidemiologically linked with each other. K. pneumoniae were confirmed to belong to the same clone, exhibiting multidrug-resistant phenotypes. One patient was positive for NDM-1-producing E. coli in blood and E. coli and K. pneumoniae in rectal specimens, both containing the same bla(NDM) plasmid, suggesting horizontal transfer between species in the patient. No environmental sources of these strains were found. Detection of positive isolates directly from rectal specimens allowed the rapid identification and isolation of colonized patients.
We report a NDM-1-producing K. pneumoniae outbreak in Ontario, Canada. Implementation of standard infection control practices, including active screening was able to contain the spread of this organism in the hospital setting. Of concern is the potential loss of a travel history to identify patients that are at high risk of being colonized or infected with this organism and the lack of an accurate, cost-effective test that can be implemented in the hospital setting to identify these multidrug-resistant organisms.
Clinical Infectious Diseases 09/2012; 55(11). DOI:10.1093/cid/cis737 · 8.89 Impact Factor
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