Retraction Notice to:
Directed Conversion of Alzheimer’s
Disease Patient Skin Fibroblasts
into Functional Neurons
Liang Qiang, Ryousuke Fujita, Toru Yamashita, Sergio Angulo, Herve Rhinn, David Rhee, Claudia Doege, Lily Chau,
Laetitia Aubry, William B. Vanti, Herman Moreno, and Asa Abeliovich*
(Cell 146, 359–371; August 5, 2011)
In this paper, we described the directed conversion of skin fibroblasts from unaffected individuals or familial Alzheimer’s disease
patients into human induced neuronal cells. We also presented molecular analyses of Alzheimer’s-associated markers in these cells.
Dr. Ryousuke Fujita, who was specifically and only responsible for the molecular analyses of Alzheimer’s-associated pathology, has
acknowledged inappropriately manipulating image panels and data points, as well as misrepresenting the number of repeats
performed, in the experiments presented in Figures 6 and 7 of the paper (and corresponding Figures S5 and S6). We are in the
processofrepeatingtheseanalyses.Giventheseissues,webelieve thatthemostappropriatecourseofactionistoretract thepaper.
We deeply regret this circumstance and apologize to the community.
514 Cell 157, 514, April 10, 2014 ª2014 Elsevier Inc.