Acute ingestion of copper sulphate: A review on its clinical manifestations and management

Indian Journal of Critical Care Medicine 04/2007; 11(2). DOI: 10.4103/0972-5229.33389
Source: OAI

ABSTRACT Ingestion of copper sulphate is an uncommon mode of poisoning in the Indian subcontinent. Cases are mainly suicidal in nature. The clinical course of the copper sulphate intoxicated patient is often complex involving intravascular hemolysis, jaundice and renal failure. The treatment is mainly supportive. In severe cases methemoglobinemia needs treatment. Mortality is quite high in severe cases. A comprehensive review of the clinical presentation and management of copper sulphate poisoning is done.

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Available from: Kavitha Saravu, Sep 27, 2015
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    • "In severe cases haematemesis and malena occur .[6] Copper is rapidly taken up by erythrocyte and result in oxidative damage and many result in haemolysis of RBC .This may account for the delayed secondary episode of haemolysis ,that occur in some copper sulphate poisoning patients [4] [7]. Intravascular haemolysis appears to be the chief factor responsible for renal lesion in these patients. "
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    DESCRIPTION: It is highlighting the role of chelating agent in acute copper sulphate poisoning
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    • "Renal failure must be recognized early by careful monitoring of serum creatinine and urine output. Though dialysis is ineffective in clearing copper from the body, it will be an essential requirement to sustain life in event of acute kidney injury [1]. Peritoneal dialysis is ineffective in maintaining the relatively longer requirement for dialysis until the renal functions recover. "
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    ABSTRACT: Copper sulphate ingestion (accidental or deliberate) is a rare form of poisoning usually limited to the Indian subcontinent. Though the rates are on the decline, it is essential that physicians are aware of its lethal complications and management strategies. The main complications of copper sulphate ingestion include intravascular haemolysis, methaemoglobinaemia, acute kidney injury and rhabdomyolysis. The lethal dose can be as small as 10 grams. We have explored the complications of acute copper sulphate poisoning with examples from two case presentations. We also recommend measures for prevention of such events.
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