Synthesis and biological characterization of anti-estrogen conjugates
ETD Collection for Purdue University
The overall function of estrogen receptor modulators and their role in the signaling of estrogen receptors through non-classical pathways is poorly understood. One possible method to answer to this question is to develop chemical tools to selectively target non-classical ER signaling pathways. The development of molecules that localize to specific subcellular areas offers a potential way to study non-classical ER signaling mechanisms. Conjugation of drugs to macromolecular scaffolds is a well-established strategy to modulate drug properties but stable conjugates have rarely been used to target steroid hormone receptors. Tamoxifen (TAM) is used extensively to treat breast cancer, but the signaling mechanisms associated with TAM are quite complex. In an effort to better understand tamoxifen action in cells and to explore the possibility of targeting nuclear receptors with conjugates, we have developed several polymer and fluorescent conjugates with unexpected cellular activities, and unique localization patterns.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.