The common variant in the GSTM1 and GSTT1 genes is related to markers of oxidative stress and inflammation in patients with coronary artery disease

Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, China.
Molecular Biology Reports (Impact Factor: 2.02). 10/2009; 37(1):405-10. DOI: 10.1007/s11033-009-9877-8
Source: PubMed


Recent studies suggest that the common variant in the GSTM1 and GSTT1 genes modifies the risk of coronary artery disease (CAD), however, it is unclear whether the risk of CAD modulated by variants in the GSTM1 and GSTT1 genes was associated with alterations of indices of oxidative stress and inflammation. Our study is an attempt to provide insight into the role of GST genetic variant and markers of oxidative stress and inflammation in CAD patients. A total of 719 Chinese CAD patients were successfully genotyped. Plasma total antioxidant status (TAOS), glutathione(GSH), C-reactive protein (CRP), fibrinogen (FIB) and white blood cell count (WBC) were determined to evaluate the oxidative stress and inflammatory response. The correlations between GSTM1/GSTT1 genotypes and alterations of indices of oxidative stress and inflammation were analyzed. We found GSTM1-0/GSTT1-0 subjects had higher CRP and FIB and lower TAOS compared to patients with wild-type GSTM1/GSTT1 genes. A stepwise elevations in age, the incidences of hypertension and diabetes mellitus, levels of FIB and the number of WBC were associated with increased number of stenosed vessels. Reductions of plasma TAOS and GSH were associated with increased number of stenosed vessels. Our results suggest that GST polymorphisms maybe modify the effect on markers of oxidative stress and inflammation in Chinese CAD patients.

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    • "These include two structural variants that deleted GSTM1 and GSTT1 genes (positive/null genotype) and two nonsynonymous substitutions of GSTP1 (i.e., GSTP1*I105V, rs1695; GSTP1*I114V, rs1138272) (Bolt and Thier, 2006; Dragovic et al., 2014). The effect of these variants in influencing disease risk was evaluated with respect to different pathologic conditions: endocrinologic (Amer et al., 2011; Mastana et al., 2013), neurologic (Kiyohara et al., 2010; Piacentini et al., 2012), cardiovascular (Polimanti et al., 2011b; Tang et al., 2010), pregnancy related (Polimanti et al., 2012), infertility related (Safarinejad et al., 2010), and allergic disease related (Minelli et al., 2010; Piacentini et al., 2014). In addition to their putative involvement in different pathologic conditions, several studies have shown that these genetic variants appear at varying frequencies among human populations (Iorio et al., 2014; Polimanti et al., 2013). "
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