Juster RP, McEwen BS, Lupien SJ. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev 35: 2-16

Laboratory of Psychoneuroendocrinology of the Centre for Studies on Human Stress, Fernand-Seguin Research Centre, University of Montreal, Canada.
Neuroscience & Biobehavioral Reviews (Impact Factor: 8.8). 10/2009; 35(1):2-16. DOI: 10.1016/j.neubiorev.2009.10.002
Source: PubMed


The allostatic load model expands the stress-disease literature by proposing a temporal cascade of multi-systemic physiological dysregulations that contribute to disease trajectories. By incorporating an allostatic load index representing neuroendocrine, immune, metabolic, and cardiovascular system functioning, numerous studies have demonstrated greater prediction of morbidity and mortality over and beyond traditional detection methods employed in biomedical practice. This article reviews theoretical and empirical work using the allostatic load model vis-à-vis the effects of chronic stress on physical and mental health. Specific risk and protective factors associated with increased allostatic load are elucidated and policies for promoting successful aging are proposed.

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Available from: Robert-Paul Juster, Mar 12, 2014
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    • "symptoms, cognitive decline, physical/mobility limitations, and neurological atrophy [11] [12] [13]) that parallel associations found in sleep medicine. While it has been hypothesized that sleep deprivation causes AL [7], sleep has received limited attention in the AL literature. "
    Sleep Medicine 11/2014; 16(1). DOI:10.1016/j.sleep.2014.07.029 · 3.15 Impact Factor
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    • "A negative spiral seems to be created wherein amygdala hyperactivity leads to increased metabolic dysfunction, which in turn instigates dysfunction of emotion regulation circuitry and increased sensitivity to threatening cues, further increasing the risk of metabolic consequences (McIntyre et al., 2007). The trajectory of depressive disease starts early and continues unless addressed by effective and targeted interventions (McEwen, 2003; Juster et al., 2010; Dannlowski et al., 2012). We therefore suggest that the first priority in treating pediatric depression should be to normalize amygdala and limbic hyperactivity and ACC dysfunction by specially designed practice as outlined in the later sections of this article. "
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    Frontiers in Human Neuroscience 08/2014; 8:1. DOI:10.3389/fnhum.2014.00630 · 2.99 Impact Factor
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    • "The proposed conceptual model comes with several potential implications. First, biomarkers have been proposed to assess differences in allostatic load between populations of adults (Juster et al. 2010, 2011). while not specific for CvS, these tests could assess the validity of the proposed framework that CvS is characterized by allostatic load, as measured by altered circadian patterns and stress-induced changes in autonomic, neuroendocrine, and even metabolic and immune factors. "
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    ABSTRACT: Cyclic vomiting syndrome (CVS) is an idiopathic illness characterized by stereotypic and sudden-onset episodes of intense retching and repetitive vomiting that are often accompanied by severe abdominal pain. Many associated factors that predict CVS attacks, such as prolonged periods of fasting, sleep deprivation, physical and emotional stress, or acute anxiety, implicate sympathetic nervous system activation as a mechanism that may contribute to CVS pathogenesis. Furthermore, adult patients with CVS tend to have a history of early adverse life events, mood disorders, chronic stress, and drug abuse-all associations that may potentiate sympathetic neural activity. In this review, we set forth a conceptual model in which CVS is viewed as a brain disorder involving maladaptive plasticity within central neural circuits important for allostatic regulation of the sympathetic nervous system. This model not only can account for the varied clinical observations that are linked with CVS, but also has implications for potential therapeutic interventions. Thus, it is likely that cognitive behavioral therapy, stress management ("mind-body") interventions, regular exercise, improved sleep, and avoidance of cannabis and opiate use could have positive influences on the clinical course for patients with CVS.
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