To evaluate the US Preventative Services Task Force (USPSTF) recommendation to discontinue prostate-specific antigen (PSA) screening at age 75.
Public survey: A cohort of 340 patients was surveyed at our PSA screening clinic and stratified by awareness of the recommendation and education level. Age (< 75, >or= 75), race, health insurance status, knowledge of prostate cancer, and opinion on screening discontinuation at age 75 was evaluated between groups. Disease risk and survival analysis: A cohort of 4196 men who underwent radical prostatectomy between 1988 and 2008 was stratified into age groups: < 65, 65-74, and >or= 75. Associations between clinicopathologic variables, disease risk, and survival were compared between age groups using univariate and multivariate analysis.
Approximately 78% of men surveyed disagreed with the USPSTF recommendation. The number of men who disagreed was not significantly different between awareness groups (P = .962). Awareness of new screening guidelines showed a significant difference (P = .006) between education groups. Age >or= 75 years was predictive of high-risk disease based on D'Amico's criteria (odds ratio = 2.72, P = .003). Kaplan-Meier and Cox regression analyses showed an association of men aged >or= 75 years with higher rate of PSA recurrence, distant metastasis, and disease specific death compared with the age groups of < 65 and 65-74 (P <.05).
Men presenting to our PSA screening clinic disagreed with discontinuation of screening at age 75. Men aged >or= 75 years had higher risk disease and poorer survival. The USPSTF recommendation was supported neither by public opinion nor disease risk and survival results.
[Show abstract][Hide abstract] ABSTRACT: Collaboration around Research and Education (CARE) was a partnership funded by the United States Department of Defense between two academic programs, Duke University School of Nursing (Duke) and Bennett College for Women (Bennett), an historically black college or university (HBCU). We had success across three years in our collaborative relationship. We matched underrepresented minority women students to faculty mentors to facilitate opportunities to study prostate cancer. CARE was marketed by Bennett to freshman and sophomore students who had identified a science major. Applications were accepted from a pool of students who have a 3.0 grade point average and interest in the program. Dr. Sekara R. Basavaraju (Dr. Rao) was the initial Bennett faculty mentor until his retirement in the second year of the program. Dr. Michael Cotton was hired by Bennett College for Women, and became the academic adviser and in the program's second year. He, like Dr. Rao, was responsible for the program on the Bennett campus. Following the summer internship on to graduation, students maintained weekly informal contact with the faculty mentor, and more formal monthly advising sessions took place in each semester. Overall GPAs were reported to Dr. Price at Duke for each semester through graduation.
[Show abstract][Hide abstract] ABSTRACT: Objectives:
With the widespread use of prostate-specific antigen testing, an increasing number of men are diagnosed with favorable-risk prostate cancer (PC). Recently, emphasis has been placed on active surveillance for selected men with favorable-risk PC to avoid unnecessary treatment for tumors that may be clinically insignificant. We performed a population-based analysis to assess patterns of initial treatment (IT) for a contemporary cohort of elderly men diagnosed with a favorable-risk PC in the United States.
We used the Surveillance, Epidemiology, and End Results database to identify men aged more than or equal to 70 years diagnosed with a favorable-risk PC from 2004 to 2008. Multivariable logistic regression analyses were performed to determine patient, tumor, and socioeconomic factors associated with IT.
A total of 15,108 men more than or equal to 70 years with a favorable-risk PC were identified. Prostatectomy was performed in 2.6% of patients. Fifty-nine percent of patients were recommended to undergo radiation therapy (RT). Among patients 70 to 74 years, 66.45% were recommended to undergo RT. Fifty-nine percent, 36.6%, and 15.8% of patients between 75 and 79, 80 and 84, and more than or equal to 85 years were recommended to receive RT, respectively. Factors significantly associated with IT on multivariable logistic regression analysis included: younger age, white race, Gleason Score 6 (vs.≤5), married marital status, and no history of prior malignancy. We also identified significant geographic variations in patterns of IT.
A large percentage of elderly men diagnosed with favorable-risk PC undergo IT, most commonly with RT. Future research should be performed to identify barriers to patient and physician acceptance of active surveillance.
American journal of clinical oncology 08/2012; 36(6). DOI:10.1097/COC.0b013e318261056c · 3.06 Impact Factor
Shousen Wang, Bingyang Xu, Qingshuang Zhao, Jun Li, Jingfang Hong, Liangfeng Wei, Lin Zhao,
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