Article

Genetic epidemiology of smoking behavior and nicotine dependence.

Department of Public Health, University of Helsinki, Finland.
COPD Journal of Chronic Obstructive Pulmonary Disease (impact factor: 1.79). 08/2009; 6(4):304-6. pp.304-6
Source: PubMed

ABSTRACT The genetic epidemiology of smoking behavior and nicotine dependence is reviewed. Twin, family and adoption studies show consistent evidence for genetic effects on many aspects of smoking behavior and nicotine dependence, while molecular genetic analyses have only recently identified genes consistently associated with nicotine dependence and amount smoked. Further studies with more sophisticated phenotypes, larger sample sizes and better measures of the environment are needed.

0 0
 · 
0 Bookmarks
 · 
28 Views
  • Source
    Article: Knowledge, attitudes and preferences regarding genetic testing for smoking cessation. A cross-sectional survey among Dutch smokers.
    Marieke Quaak, Chris Smerecnik, Frederik J van Schooten, Hein de Vries, Constant P van Schayck
    [show abstract] [hide abstract]
    ABSTRACT: Objectives Recent research strongly suggests that genetic variation influences smokers' ability to stop. Therefore, the use of (pharmaco) genetic testing may increase cessation rates. This study aims to assess the intention of smokers concerning undergoing genetic testing for smoking cessation and their knowledge, attitudes and preferences about this subject. Design Online cross-sectional survey. Setting Database internet research company of which every inhabitant of the Netherlands of ≥12 years with an email address and capable of understanding Dutch can become a member. Participants 587 of 711 Dutch smokers aged ≥18 years, daily smokers for ≥5 years and smoke on average ≥10 cigarettes/day (response rate=83%). Primary and secondary outcome measures Smokers' knowledge, attitudes and preferences and their intention to undergo genetic testing for smoking cessation. Results Knowledge on the influence of genetic factors in smoking addiction and cessation was found to be low. Smokers underestimated their chances of having a genetic predisposition and the influence of this on smoking cessation. Participants perceived few disadvantages, some advantages and showed moderate self-efficacy towards undergoing a genetic test and dealing with the results. Smokers were mildly interested in receiving information and participating in genetic testing, especially when offered by their general practitioner (GP). Conclusions For successful implementation of genetic testing for smoking in general practice, several issues should be addressed, such as the knowledge on smoking cessation, genetics and genetic testing (including advantages and disadvantages) and the influence of genetics on smoking addiction and cessation. Furthermore, smokers allocate their GPs a crucial role in the provision of information and the delivery of a genetic test for smoking; however, it is unclear whether GPs will be able and willing to take on this role.
    BMJ open. 01/2012; 2:e000321.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

adoption studies
 
amount smoked
 
aspects
 
genetic effects
 
larger sample sizes
 
nicotine dependence
 
smoking behavior
 
sophisticated phenotypes
 

Jaakko Kaprio