Article

Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting.

Institute of Clinical Medicine, University of Bergen, and Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
American journal of obstetrics and gynecology (impact factor: 3.28). 10/2009; 201(6):603.e1-7. DOI:10.1016/j.ajog.2009.07.029 pp.603.e1-7
Source: PubMed

ABSTRACT The objective of the study was to investigate the prognostic impact of deoxyribonucleic acid (DNA) ploidy in endometrial carcinoma in a routine diagnostic series as compared with a research series.
We studied a population-based series of 363 endometrial carcinomas prospectively collected, with long and complete follow-up. The prognostic value of DNA ploidy was investigated in a routine diagnostic series (n=262) and compared with the results from a previous research series (n=101).
The proportion of DNA aneuploid tumors was 21% in the research series and 25% in the routine diagnostic series (P=NS). In both series, DNA aneuploidy was significantly correlated to higher age at diagnosis, nonendometrioid subtype, and high histologic grade. Patients with DNA aneuploid tumors had significantly poorer survival, adjusted for established clinicopathologic prognostic factors.
DNA ploidy estimation in endometrial carcinoma adds independent prognostic information in a routine diagnostic setting.

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Keywords

363 endometrial carcinomas prospectively
 
clinicopathologic prognostic factors
 
complete follow-up
 
DNA aneuploid tumors
 
DNA aneuploidy
 
DNA ploidy
 
DNA ploidy estimation
 
endometrial carcinoma
 
higher age
 
histologic grade
 
independent prognostic information
 
population-based series
 
previous research series
 
prognostic impact
 
prognostic value
 
research series
 
routine diagnostic series