Found in translation: understanding impulsivity and related constructs through integrative preclinical and clinical research.

Departments of Psychiatry and the Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06519, USA.
Biological psychiatry (Impact Factor: 9.47). 10/2009; 66(8):714-6. DOI: 10.1016/j.biopsych.2009.08.004
Source: PubMed
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This study aims to explore the relationship between impulsivity traits and perceived negative consequences of alcohol consumption and Internet use. More specifically, impulsivity traits – positive and negative urgency, sensation seeking, lack of premeditation, and lack of perseverance – in (1) the occurrence of initial negative consequences linked to use, and (2) the transition from consequences possibly indicating a problematic behavior to consequences very likely indicating a clinical problem. For this, 709 firstyear college students were assessed using the UPPS-P impulsive behavior scale, and the Multicage CAD-4 scale for addictive behaviors. Logistic regressions were used to discriminate (a) between individuals with a 0-score and individuals with a 1-score in the Multicage scales (low severity range), and (b) between individuals with a 2-score and individuals with 3/4-score (high severity range), separately for alcohol and Internet use. For alcohol use, positive urgency and lack of premeditation marked the transition from 0 to 1 scores, whereas negative urgency marked the transition from 2 to 3/4 scores. For Internet use, however, none of the UPPS-P dimensions significantly marked the transition from 0 to 1 (occurrence of initial negative consequences), and positive urgency marked the transition from 2 to 3/4 (from possible to very likely problematic behavior). Negative urgency arises as a pathologization marker for alcohol abuse, whereas changes in non-clinical levels are linked to impulsivity elicited by appetitive emotions. Impulsivity does not seem to play any role in low severity levels of Internet use, and positive urgency marks the transition between high severity scores. These differential patterns are indicative of different etiological paths for excessive Internet use and substance abuse.
    Adicciones 01/2014; 26(2):159-167. · 1.17 Impact Factor
  • Source
    Addictive Behaviors 06/2014; 39(11). DOI:10.1016/j.addbeh.2014.06.005 · 2.44 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Repetitive transcranial magnetic stimulation (rTMS) has been used widely in various psychiatric disorders like depression and schizophrenia. There have been some reports of its usefulness in alcohol dependence and substance use disorders. The present paper reviews the studies done using rTMS in substance use disorders including alcohol and nicotine dependence. Various studies done have been reviewed including the proposed mechanisms of action are outlined with the future research needs and need for further clinical data.
    Autonomic neuroscience: basic & clinical 06/2013; 4(3):271-5. · 1.37 Impact Factor


Available from